Diisocyanates are the leading cause of occupational asthma, and epidemiological evidence suggests that occupational rhinitis is a comorbid and preceding condition in patients who develop asthma. The goal of the present studies was to develop and characterize a murine model of toluene diisocyanate (TDI)-induced rhinitis. Female C57BL/6 mice were exposed to workplace-relevant concentrations of TD...

To determine the validity of ultrasonic nebulization of distilled water (UNDW, "fog") in comparison with methacholine challenge, in the assessment of toluene diisocyanate (TDI) asthma, we evaluated 75 subjects exposed to TDI with work-related respiratory symptoms. Subjects were submitted to bronchial challenge with methacholine at first, thereafter to UNDW inhalation and to specific challenge w...

Cytokine Production by Splenocytes and Thymocytes in Mice after Intranasal Exposure to Toluene Diisocyanate: Kui-Cheng ZHENG, et al. Department of Preventive Medicine, School of Medicine, University of the Ryukyus—To determine the status and the role of cytokines in occupational asthma induced by toluene diisocyanate (TDI), we performed a quantitative analysis of cytokine profiles by means of s...

Toluene diisocyanate (TDI) is a leading cause of occupational asthma. Although considerable controversy remains regarding its pathogenesis, TDI-induced asthma is an inflammatory disease of the airways characterized by airway remodeling. Peroxisome proliferator-activated receptor gamma (PPARgamma) has been shown to play a critical role in the control of airway inflammatory responses. However, no...

BACKGROUND Traumatic diaphragmatic injury (TDI) is uncommon and has historically been identified by chest x-ray and repaired by laparotomy with nonabsorbable suture. Blunt TDI was more frequently (90%) detected on the left. With advances in imaging and operative techniques, our objective was to evaluate evolution in incidence, location, and management of TDI. METHODS The medical records of pa...

AIM To evaluate the prevalence of traumatic dental injuries (TDIs) and unintentional injuries (UIs) in Swedish children from 0 to 12 years of age, comparing those who were born preterm with matched full-term controls. The associations between TDI and UI and medical health problems or socio-demographic characteristics were also studied. METHODS This cross-sectional, case-control study used den...

In this paper we introduce Translation Difficulty Index (TDI), a measure of difficulty in text translation. We first define and quantify translation difficulty in terms of TDI. We realize that any measure of TDI based on direct input by translators is fraught with subjectivity and adhocism. We, rather, rely on cognitive evidences from eye tracking. TDI is measured as the sum of fixation (gaze) ...

Two mini-sequencing methods, FP-TDI (template-directed dye-terminator incorporation with fluorescence-polarization) and MassArray (matrix assisted laser desorption ionization time of flight detection mass spectrometry), were optimized. A numeric standard was introduced to evaluate the SNP scoring quality of FP-TDI assay, thus made the optimization work easier. At the same time, using multi-PCR ...

Antihistamines are effective for treatment of seasonal nasal allergy. Recently, prophylactic treatment with antihistamines in patients with pollinosis was reported to be more effective when started before the pollen season. The administration with antihistamines from 2 to 6 weeks before onset of the pollen season is recommended for management of allergic rhinitis in Japan. To determine the reas...

The photophysical properties of three new water-soluble terrylenediimide (WS-TDI) derivatives are investigated and their utilization in biological experiments is demonstrated. Each of these dyes can be excited in the far red region of the visible spectrum, making them good candidates for in-vivo studies. Single-molecule techniques characterize their photophysics that is, the number of emitted p...