To evaluate the pathogenetic role of cerebral blood flow (CBF) changes occurring before and during the development of acute mountain sickness (AMS), peak mean middle cerebral artery flow velocities () were assessed by transcranial Doppler sonography in 10 subjects at 490-m altitude, and during three 12-min periods immediately (SA1), 3 (SA2), and 6 (SA3) h after decompression to a simulated alti...

Telomeres use distinct mechanisms (not used by arms or centromeres) to mediate cohesion between sister chromatids. However, the motivation for a specialized mechanism at telomeres is not well understood. Here we show, using fluorescence in situ hybridization and live-cell imaging, that persistent sister chromatid cohesion at telomeres triggers a prolonged anaphase in normal human cells and canc...

Streptococcus anginosus is a member of the normal oral flora that can become a pathogen causing pyogenic infections in humans. The genome of daptomycin-resistant strain J4206, originally isolated from a patient suffering from breakthrough bacteremia and septic shock at the University of Texas Health Science Center at San Antonio, was determined. The circular genome is 2,001,352 bp long with a G...

Lintao Zhang 1,2,*,†, Anyuan Deng 2,†, Engang Wang 2,† and Johann Sienz 1,† 1 Advanced Sustainable Manufacturing Technologies (ASTUTE2020) Project, College of Engineering, Swansea University, Bay Campus, Fabian Way, Swansea SA1 8EN, UK; [email protected] (J.S.) 2 Key Laboratory of National Education Ministry for Electromagnetic Processing of Materials, Northeastern University, Shenyang 1100...

Research Update: Behind the high efficiency of hybrid perovskite solar cells Azhar Fakharuddin,1,2,a Francesca De Rossi,3,a Trystan M. Watson,3 Lukas Schmidt-Mende,1 and Rajan Jose4,a 1Department of Physics, University of Konstanz, D-78457 Konstanz, Germany 2School of Chemical and Materials Engineering, National University of Sciences and Technology, H-12, Islamabad, Pakistan 3College of Engine...

Fertilization and pregnancy outcomes of 50 round spermatid injection (ROSI) and 20 elongated spermatid injection (ELSI) treatment cycles are related to various characteristics of the cycles, with particular reference to spermatid developmental stage as assessed by using a classification scheme adapted to this purpose. Although this classification includes eight stages, a complete block was most...

Extended suprathreshold vibratory stimulation applied to the skin results in a desensitization of cutaneous mechanoreceptive afferents. In a companion paper, we describe the dependence of the threshold shift on the parameters of the adapting stimulus and discuss neural mechanisms underlying afferent adaptation. Here we describe the time-course of afferent adaptation and recovery. We found that ...

Genomic RNA of HIV-1 contains localized structures critical for viral replication. Its structural analysis has demonstrated a stem-loop structure, SLSA1, in a nearby region of HIV-1 genomic splicing acceptor 1 (SA1). We have previously shown that the expression level of vif mRNA is considerably altered by some natural single-nucleotide variations (nSNVs) clustering in SLSA1 structure. In this s...