نتایج جستجو برای: قارچ mortierella alpina

تعداد نتایج: 7933  

Journal: :Applied and environmental microbiology 2000
D A Mackenzie P Wongwathanarat A T Carter D B Archer

Mortierella alpina was transformed successfully to hygromycin B resistance by using a homologous histone H4 promoter to drive gene expression and a homologous ribosomal DNA region to promote chromosomal integration. This is the first description of transformation in this commercially important oleaginous organism. Two pairs of histone H3 and H4 genes were isolated from this fungus. Each pair co...

Journal: :Microbiology 2011
Hongchao Wang Bo Yang Guangfei Hao Yun Feng Haiqin Chen Lu Feng Jianxin Zhao Hao Zhang Yong Q Chen Lei Wang Wei Chen

We characterized the de novo biosynthetic pathway of tetrahydrobiopterin (BH₄) in the lipid-producing fungus Mortierella alpina. The BH₄ cofactor is essential for various cell processes, and is probably present in every cell or tissue of higher organisms. Genes encoding two copies of GTP cyclohydrolase I (GTPCH-1 and GTPCH-2) for the conversion of GTP to dihydroneopterin triphosphate (H₂-NTP), ...

Journal: :Bioprocess and biosystems engineering 2012
Yan Zeng Xiao-Jun Ji Shu-Mei Chang Zhi-Kui Nie He Huang

To improve the arachidonic acid (ARA) accumulation in Mortierella alpina, a mixed B-group vitamin addition strategy was developed. The ARA titer reached up to 10.0 g/L, 1.7-fold of the control. At the same time, the highest specific activities of key enzymes involved in ARA biosynthesis, including malic enzyme, glucose-6-phosphate dehydrogenase and ATP: citrate lyase, were 63.3, 38.6 and 53.7% ...

Journal: :Applied and Environmental Microbiology 2021

Fungal natural compounds are industrially produced, with application in antibiotic treatment, cancer medications, and crop plant protection. Traditionally, higher fungi have been intensively investigated concerning their metabolic potential, but reidentification of already known is frequently observed. Hence, alternative strategies to acquire novel bioactive molecules required. We present the g...

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