Consider the semi-parametric linear regression model Y = ′X+ , where has an unknown distribution F0. The semi-parametric MLE
̃ of under this set-up is called the generalized semi-parametric MLE(GSMLE).Although the GSML estimation of the linear regression model is statistically appealing, it has never been attempted due to difficulties with obtaining the GSML estimates of and F until recent work...

Maximum likelihood estimation (MLE) methods are widely used for evolutionary tree. As evolutionary tree is not a smooth parameter, the consistency of its MLE has been a topic of debate. It has been noted without proof that the classical proof of consistency by Wald holds for the MLE of evolutionary tree. Other proofs of consistency under various models were also proposed. Here we will discuss s...

The diffusion of the use of the learning virtual environments presents a great potential for the development of an application which meet the necessities in the education area. In view of the importance of a more dynamic application and that can adapt itself continuously to the students’ necessities, the “U-ALS” (Ubiquitous Adapted Learning System) was proposed and developed. This system was bu...

Maleless (mle) is essential in Drosophila melanogaster males both in somatic cells and in germ cells. In somatic cells mle is necessary for X-chromosome dosage compensation. The role of mle in the germline is unknown. We have analyzed the expression pattern and localization of MLE, the other MSLs and acetylated isoforms of histone H4 in male germ cells to address whether dosage compensation and...

The DNA repair protein Ku70 is a key player in chemoresistance to anticancer agents (e.g., etoposide) or radioresistance. The responses of different organs to radiation vary widely and likely depend on the cell population in the organs. Previously, we established and characterized Ku70-deficient murine lung epithelial (Ku70 -/- MLE) cells and found that these cells are more sensitive than Ku70 ...

When in a full exponential family the maximum likelihood estimate (MLE) does not exist, the MLE may exist in the Barndorff-Nielsen completion of the family (BarndorffNielsen, 1978; Brown, 1986; Geyer, 1990). A practical algorithm for finding the MLE in the completion using repeated linear programming was proposed in the author’s unpublished thesis (Geyer, 1990) and used in Geyer and Thompson (1...

We propose a new parsimonious version of the classical multivariate normal linear model, yielding a maximum likelihood estimator (MLE) that is asymptotically less variable than the MLE based on the usual model. Our approach is based on the construction of a link between the mean function and the covariance matrix, using the minimal reducing subspace of the latter that accommodates the former. T...

Efficacy of Morinda citrifolia L. leaf (MLE) and fruit extracts (MFE) in inhibiting lipoprotein lipase (LPL) was determined in vitro. The result of the study showed that the highest inhibition on the LPL activity was exhibited by MLE (66%+/- 2.1%), which is significantly higher than that demonstrated by MFE (54.5%+/- 2.5%), green tea extract (GTE) (54.5%+/- 2.6%), and catechin (43.6%+/- 6.1%). ...

Helicases are ubiquitous enzymes that unwind or remodel single or double-stranded nucleic acids, and that participate in a vast array of metabolic pathways. The ATP-dependent DEXH-box RNA/DNA helicase MLE was first identified as a core member of the chromatin remodeling MSL complex, responsible for dosage compensation in Drosophila males. Although this complex does not assemble in females, MLE ...

Helicases are ubiquitous enzymes that unwind or remodel single or double-stranded nucleic acids, and that participate in a vast array of metabolic pathways. The ATP-dependent DEXH-box RNA/DNA helicase MLE was first identified as a core member of the chromatin remodeling MSL complex, responsible for dosage compensation in Drosophila males. Although this complex does not assemble in females, MLE ...