Hepatic ischaemia/reperfusion (I/R) injury is of primary concern during liver surgery. We propose a new approach for preserving low liver blood perfusion during hepatectomy either by occlusion of the portal vein (OPV) while preserving hepatic artery flow or occlusion of the hepatic artery while limiting portal vein (LPV) flow to reduce I/R injury. The effects of this approach on liver I/R injur...

BACKGROUND The tablet formulation of ritonavir-boosted lopinavir (LPV/r; Kaletra) has many advantages over the soft gel capsule (SGC) formulation, including lower pill count, no refrigeration requirement, and no dietary restrictions. These advantages may help improve patient compliance and therefore increase adherence to treatment. However, there are limited data regarding patient preferences a...

This paper is concerned with the application of advanced Linear Parameter-Varying (LPV) techniques to the global control of a missile. The LPV technique considered in this paper is an extension of the standard H 1 synthesis technique to the case where the plant depends aanely on a time-varying vector (t). Working in the class of LPV plants, the proposed methodology produces an LPV controller. T...

introduction: this study evaluated the effects of pretreatments with melatonin (mt), and alpha lipoic acid (ala) on lopinavir/ritonavir (lpv/r) -induced serum levels of creatinine (cr), urea (u), uric acid (ua) and kidney levels of malondialdehyde (mda), superoxide dismutase (sod), glutathione (gsh) and catalase (cat) in male albino rats. effects of treatments with mt and ala were also evaluate...

INTRODUCTION During pregnancy, LPV/r is a common anchor drug employed to treat the mother's HIV-1 infection in addition to reducing the risk of mother-to-child transmission (MTCT). The National Study of HIV in Pregnancy and Childhood (NSHPC) conducts a comprehensive population-based surveillance of HIV infection in pregnant women exposed to antiretroviral therapy (ART) in the UK and Ireland; in...

Parametric identification approaches in the Linear Parameter-Varying (LPV) setting require optimal prior selection of a set of functional dependencies, used in the parametrization of the model coefficients, to provide accurate model estimates of the underlying system. Consequently, data-driven estimation of these functional dependencies has a paramount importance, especially when very limited a...

We consider stability analysis and state feedback synthesis for Linear Parameter Varying (LPV) systems. LPV systems are de"ned as linear systems whose dynamics depend on exogenous time-varying parameters. Stability analysis of LPV systems involves testing the stability of a family of possible parameter trajectories. Similarly, stabilization and optimal control of LPV systems involves constructi...

PURPOSE Double protease inhibitor (PI) boosting is being explored as a new strategy in salvage antiretroviral (ARV) therapy. However, if a negative drug interaction leads to decreased drug levels of either or both PIs, double PI boosting could lead to decreased virologic response. A negative drug interaction has been described between amprenavir (APV) and lopinavir/ritonavir (LPV/r). This obser...

OBJECTIVE To compare changes over 48 weeks in bone mineral density (BMD) between participants randomized to lopinavir/ritonavir (LPV/r) + raltegravir (RAL) or LPV/r + 2-3 nucleoside/nucleotide reverse transcriptase inhibitors (N(t)RTIs) as second line therapy. DESIGN 48-week open-label sub-study of the Second Line trial conducted in South Africa, India, Thailand, Malaysia and Argentina. MET...

In this paper an LPV rational order control model of an irrigation canal is experimentally obtained by using the described LPV fractional identification procedure. Global LPV model is obtained from polynomial interpolation of local model parameters. Validation results demonstrate that rational order models are more accurate than integer order models. Therefore rational order models of an irriga...