This contribution brings to a close a special issue of Hydrology and Earth System Sciences concerning the assessment of nitrogen dynamics in catchments across Europe within a semi-distributed Integrated Nitrogen model for multiple source assessment in Catchments (INCA). The wide range of issues involved in relation to hydrology and within-catchment processes, scale (from small catchments to maj...

Sequencing of pJIE512b, a 92.3-kb IncI1 sequence type 2 (ST2) plasmid carrying bla(CMY-2), revealed a bla(CMY-2) context that appeared to have been mobilized from an IncA/C plasmid by the insertion sequence IS1294. A comparison with published plasmids suggests that bla(CMY-2) has been mobilized from IncA/C to IncI1 plasmids more than once by IS1294-like elements. Alignment of pJIE512b with the ...

The incA gene product of ColE2-P9 and ColE3-CA38 plasmids is an antisense RNA that regulates the production of the plasmid-coded Rep protein essential for replication. The Rep protein specifically binds to the origin and synthesizes a unique primer RNA at the origin. The IncB incompatibility is due to competition for the Rep protein among the origins of the same binding specificity. We localize...

The European Commission developed an amendment to Regulation 691/2011 on environmental economic accounts include reporting ecosystem compliant the United Nations Statistical System of Environmental-Economic Accounts – Ecosystem (SEEA-EA) standard. To support Member States implementing this regulation, open source tool, known as INCA-tool, generate service has been developed, based Knowledge Inn...

This section of the Handbook deals with the culture of the Andean region between Ecuador and the northern border of Aymara territory as it was observed by the Spanish conquerors in the 16th century and recorded in surviving documents. This area includes the whole of the desert Coast of Perti and the broken valleys of the Peruvian Highlands, a region which was the home of many different tribes, ...

Pathological response of breast cancer to neoadjuvant chemotherapy (NAC) presents great variability, and new prognostic biomarkers are needed. Our aim was to evaluate the association of the epidermal growth factor receptor gene (EGFR) polymorphism R497K (rs2227983) with prognostic features and clinical outcomes of breast cancer, including the pathological response to NAC and the recurrence-free...