AIMS Isthmin (ISM) is a recently identified 60 kDa secreted angiogenesis inhibitor. Two cell-surface receptors for ISM have been defined, the high-affinity glucose-regulated protein 78 kDa (GRP78) and the low-affinity αvβ5 integrin. As αvβ5 integrin plays an important role in pulmonary vascular permeability (VP) and ISM is highly expressed in mouse lung, we sought to clarify the role of ISM in ...

The title requires some explanation. The term “IP-ism” was introduced by the author in [1] to name the current trend which tends to treat IP-related technology as an ideology – an “-ism” – rather than just one of many possible solutions within the ICT area. In short, according to IP-ism, the IP technology (its derivatives, modifications etc.) is regarded as a panacea for the development of a fu...

Prophages are common in many bacterial genomes. Distinguishing putatively viable prophages from nonviable sequences can be a challenge, since some prophages are remnants of once-functional prophages that have been rendered inactive by mutational changes. In some cases, a putative prophage may be missed due to the lack of recognizable prophage loci. The genome of a marine roseobacter, Roseovariu...

Methods of functional brain imaging have been used to identify brain structures which are active during internal simulation of movements (ISM). Between 1977 and 1993 it was consistently reported that the primary motor cortex (MI) is not active during ISM whereas other cortical areas, in particular the supplementary motor area (SMA) are active. ISM was assumed to be a situation of "internal prog...

3 The Copernicus Era 17 3.1 Cloudy Sightlines: ζ Oph . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 3.2 Intercloud Material . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 3.3 Deuterium . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 3.4 Molecular Hydrogen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 3.5 The Distrib...

Ideas by Statistical Mechanics (ISM) is a generic program to model evolution and propagation of ideas/patterns throughout populations subjected to endogenous and exogenous interactions. The program is based on the author’s work in Statistical Mechanics of Neocortical Interactions (SMNI), and uses the author’s Adaptive Simulated Annealing (ASA) code for optimizations of training sets, as well as...