‘Laser microdissection: a day for answers conference,’ organized by EuroSciCon (Hertfordshire, UK), hosted a large group of scientists from across Europe. Laser-capture microdissection (LCM) is a state-of-the-art technique that has made a large impact amongst the scientific community in recent times. Despite the usefulness of this technique, LCM is still relatively underused and, thus, the main...

Received March 13, 2007 Abstract For any positive integer n, the Smarandache LCM dual function SL∗(n) is defined as the greatest positive integer k such that [1, 2, · · · , k] divides n. The main purpose of this paper is using the elementary method to study the calculating problem of a Dirichlet series involving the Smarandache LCM dual function SL∗(n) and the mean value distribution property o...

This study used finite element (FE) analysis with the load-controlled method (LCM) and the displacement-controlled method (DCM) to examine motion differences at the implant level and adjacent levels between fusion and non-fusion implants. A validated three-dimensional intact (INT) L1-L5 FE model was used. At the L3-L4 level, the INT model was modified to surgery models, including the artificial...

Four ruminally cannulated buffalo bulls (300 kg) were fed mottgrass diets using a 4 4 Latinsquare design. Treatments consisted of mottgrass fertilized with 0 or 110.4 kg N/ha and harvested at 40 (ECM) and 60 (LCM) days. Fertilization increased the concentrations of crude protein (CP) and fibre contents. The CP contents of the mottgrass decreased and fibre contents increased with advancing matur...

Tissue injury (chronic disease) associated with persistent LCM infection is apparently caused by the host immune response to the virus. Employing parabiosis or cell transfer from hyperimmune donors to isologous virus carriers, the tissue injury of chronic disease could be initiated and/or intensified. Furthermore, the transfer of anti-LCM antibody to SWR/J carrier mice results in acute necrotiz...

Due to the complexity of Alzheimer's disease, multiple cellular types need to be targeted simultaneously in order for a given therapy to demonstrate any major effectiveness. Ultrasound-sensitive coated microbubbles (in a targeted lipid nanoemulsion) are available. Versatile small molecule drug(s) targeting multiple pathways of Alzheimer's disease pathogenesis are known. By incorporating such dr...

Lymphocytic choriomeninigitis (LCM) virus defective interfering (DI) particles form foci of protected cells in a monolayer under an agarose-containing overlay medium. Foci originate from one cell dually infected with at least 1 interference focus-forming unit and infectious virus. As a result, an interfering factor is produced and released which interacts with neighboring cells, thereby protect...

Lacosamide (LCM) is an antiepileptic drug approved as adjunctive therapy for partial-onset seizures in adults. It has a mechanism of action that differs from other antiepileptic drugs in that it selectively enhances sodium channel slow inactivation, which is in contrast to 'traditional' sodium channel blockers (e.g., carbamazepine, oxcarbazepine, lamotrigine and phenytoin) that primarily affect...

The ability to reliably analyze cellular and molecular profiles of normal or diseased tissues is frequently complicated by the inherent heterogeneous nature of tissues. Laser Capture Microdissection (LCM) is an innovative technique that allows the isolation and enrichment of pure subpopulations of cells from tissues under direct microscopic examination. Material obtained by LCM can be used for ...

Lacosamide (LCM) is a novel agent that has been developed as an antiepileptic drug. In vitro studies suggest that LCM modulates voltage-gated sodium channels by enhancing their slow inactivation. In addition, LCM seems to interact with collapsin-response mediator protein 2 and thus may mediate neuronal plasticity. LCM has an elimination half-life of 13 hours, no relevant protein binding, and do...