Sparsity-inducing multiple kernel Fisher discriminant analysis (MK-FDA) has been studied in the literature. Building on recent advances in non-sparse multiple kernel learning (MKL), we propose a non-sparse version of MK-FDA, which imposes a general lp norm regularisation on the kernel weights. We formulate the associated optimisation problem as a semi-infinite program (SIP), and adapt an iterat...

OBJECTIVE The prognosis for gastric carcinoma patients with liver metastasis is very poor. This retrospective study investigated the prognostic significance of MK-1 expression in gastric carcinoma patients with liver metastasis. METHODS Immunohistochemical staining using monoclonal antibody FU-MK-1 against MK-1 antigen was performed on paraffin-embedded tissues from 64 gastric carcinoma patie...

The amount of DNA in individual megakaryocytes (MK) was measured by Feulgen photometry performed on smears of steady-state rat bone marrow. The MK were identified by acetylcholinesterase (ACHE) staining. The method described is particularly suitable in the study of immature MK, hitherto difficult to examine for DNA content. The main MK ploidies were 8N, 16N, and 32N, comprising 33.4% +/- 1.4%, ...

OBJECTIVE The aim of this study was to determine the biological effects of natural dietary intake of vitamin K as phylloquinone (K(1)) and menaquinone-4 (MK-4) and a control diet also containing menadione (K(3)) on levels of K(1) and total MK-4 (menaquinone-4) and menaquinone-4-2,3-epoxide (MK-4O)) in liver and pancreas, and on femur bending resistance in a fast-growing animal model. DESIGN C...

RATIONALE The mitochondrial ATP sensitive potassium channel (mK(ATP)) is implicated in cardioprotection by ischemic preconditioning (IPC), but the molecular identity of the channel remains controversial. The validity of current methods to assay mK(ATP) activity is disputed. OBJECTIVE We sought to develop novel methods to assay mK(ATP) activity and its regulation. METHODS AND RESULTS Using a...

Midkine (MK) is the first cloned gene in a new family of heparin-binding growth/differentiation factors involved in the regulation of growth and differentiation. We have analyzed the expression of MK mRNA and protein during tooth development in mouse embryos and studied the regulation of MK expression and the biological effects of MK protein in organ cultures. MK expression was restricted and p...

Abstract Study was related to the influence of concrete properties by using different percentages metakaolin and fixed percent incineration bottom ash partially replace cement. Cement is a well-known building material used for construction in world. Moreover, (MK) (IBA) this research would give significance our environment as it can reduce usage cement concrete. By ash, could land filling space...

BACKGROUND Current data on antidepressant action of the N-methyl-D-aspartate receptor antagonist, (+)-MK-801, is inconsistent. This study was conducted to examine the effects of (+)-MK-801 and its less potent stereoisomer, (-)-MK-801, in the social defeat stress model of depression. METHODS The antidepressant effects of (+)-MK-801 (0.1mg/kg) and (-)-MK-801 (0.1mg/kg) in the social defeat stre...

Optimal conditions necessary for the cytochemical demonstration of megakaryocyte (Mk) and platelet acid phosphatase (AP) were determined. Methanol, a constituent of fixatives commonly used in AP cytochemistry, was found to inhibit MkAP, and the degree of inhibition varied with Mk maturity. Immature Mk contained predominantly methanol-resistant AP, and mature Mk, predominantly methanol-sensitive...

be a power series with the radius of convergence 1. We say that it has Ostrowski gaps p if there exists a pi, such that | an \ < pn for mk á « Û «*. It has infinite Ostrowski gaps p (pp there corresponds a pair of infinite sequences mk and nk (depending on p') with mk<nk and lim nk/mk= « such that | a» | ...