نتایج جستجو برای: مدلhec ras
تعداد نتایج: 29885 فیلتر نتایج به سال:
EXTRACT Although there are new ways to portray the brain, colored and computerized encephalography but Coma is still unknown and such as death remain beyond comprehension and knowing. Is not it ? Perhaps because of this, despite knowing that some part of the brain is not yet fully understood all its parts. But knowing the components that working to each other is key for discovering a lot of...
هدف: سرطان کولورکتال یکی از شایعترین سرطانها در جهان است. بدیهی است که درک رفتار تومور و در سطح مولکولی به درمانی اثربخش تر و پیش آگهی دقیق تری در مورد بیماری می انجامد. از بین تمامی ژنهایی که در سرطان کولورکتال دچار تغییر می شوند، k-ras از اهمیت تشخیصی و پیش آگهی قابل توجهی برخوردار است. جهشهای k-ras از جمله وقایع کلیدی در سرطانزایی کولورکتال به حساب می آیند. بررسیهای گذشته نشان داده اند که به...
Ras GTPases include the isoforms H-Ras, K-Ras, and N-Ras. Despite their great biochemical and biological similarities, evidence is mounting suggesting that Ras proteins may not be functionally redundant. A widespread strategy for studying small GTPases is the utilization of dominant inhibitory mutants that specifically block the activation of their respective wild-type proteins. As such, H-Ras ...
R-Ras promotes cell adhesion and activation of integrins through a process that is yet unknown. We show here that active R-Ras (38V) promotes the formation of focal adhesions and a spread cell shape. By contrast, the dominant-negative mutant of R-Ras (43N) reduces the number of focal adhesions, leading to the formation of refractile cells. In adherent cells wild-type R-Ras, activated (38V) R-Ra...
background: domestic and industrial wastewaters are mostly treated by biological process such as activated sludge, aerobic pond, and anaerobic treatment. this study focuses on characterizing the quality of sewage sludge in the sultanate of oman chosen from three industrial sewage treatment plants (stps): rusayl industrial estate (rsl.ie); sohar industrial estate (sie); and raysut industrial est...
The use of reclaimed asphalt pavement (RAP) and/or recycled shingles (RAS) in the mixtures is a common practice U.S.A. However, there controversy to date on how RAP/RAS interact with virgin binders (VABs) mixtures. For containing RAP/RAS, aged RAP and air-blown RAS alter performances extracted (EABs). Thus, rheological properties EABs from these require more investigation. focus this paper was ...
The recirculating aquaculture system (RAS) is a cultivation that minimizes water changes and can optimize high stocking densities (SD). purpose of this study was to determine the effect nursery culture in density with RAS on survival rate (SR), specific growth (SGR), relative length (LR), weight gain (WG), (LG)and feed utility efficiency (FUE) juvenile catfish. used completely randomized design...
The role of three major Ras downstream effector pathways in the induction of mammary cancer was studied using an in situ mammary ductal gene delivery model. Replication-defective retroviral vectors were used to infect endogenous rat mammary epithelial cells with three individual Ras effector loop mutants, each of which transduces its signal through a different Ras effector pathway (Raf, PI3K or...
E-RAS is a member of the RAS family specifically expressed in embryonic stem cells, gastric tumors, and hepatic stellate cells. Unlike classical RAS isoforms (H-, N-, and K-RAS4B), E-RAS has, in addition to striking and remarkable sequence deviations, an extended 38-amino acid-long unique N-terminal region with still unknown functions. We investigated the molecular mechanism of E-RAS regulation...
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