We recently demonstrated that extracellular ATP effectively activates adenosine (Ade) A(2B) receptors indirectly through a localized rapid conversion to Ade by ectonucleotidases on the membrane surface of C6Bu-1 rat glioma cells. These responses were observed even in the presence of adenosine deaminase (ADA). Here, we demonstrate that such responses indeed occur in A(2B) receptor-expressing Xen...

BACKGROUND Marburg virus (MARV) and Ebola virus (EBOV) cause severe hemorrhagic fever in primates. Earlier studies demonstrated that antibodies to particular epitopes on the glycoprotein (GP) of EBOV enhanced virus infectivity in vitro. METHODS To investigate this antibody-dependent enhancement (ADE) in MARV infection, we produced mouse antisera and monoclonal antibodies (mAbs) to the GPs of ...

Adverse events detection is critical in many fields, e.g., adverse drug event (ADE) detection in medical field. ADE is an unexpected and harmful consequence of drug usage. Many researchers found that identifying the correlation between the use of drugs and adverse events from biomedical literature can contribute a lot to drug safety monitoring. In this paper, we propose a novel approach based o...

We use F. Ferrari’s methods relating matrix models to Calabi-Yau spaces in order to explain much of Intriligator and Wecht’s ADE classification of N = 1 superconformal theories which arise as RG fixed points of N = 1 SQCD theories with adjoints. We find that ADE superpotentials in the Intriligator–Wecht classification exactly match matrix model superpotentials obtained from Calabi-Yaus with cor...

Reliable evaluation for the performance of classifiers depends on the quality of the data sets on which they are tested. During the collecting and recording of a data set, however, some noise may be introduced into the data, especially in various real-world environments, which can degrade the quality of the data set. In this paper, we present a novel approach, called ADE (automatic data enhance...

OBJECTIVES To assess Texas pharmacists' knowledge of adverse drug event (ADE) reporting to the Food and Drug Administration (FDA) and to determine demographic and practice characteristics associated with this knowledge. DESIGN Cross-sectional descriptive study. SETTING Austin, TX, in June and July 2009. PARTICIPANTS 377 pharmacists practicing in hospital and community settings. INTERVEN...

BACKGROUND The IOM report, Preventing Medication Errors, emphasizes the overall lack of knowledge of the incidence of adverse drug events (ADE). Operating rooms, emergency departments and intensive care units are known to have a higher incidence of ADE. Labor and delivery (L&D) is an emergency care unit that could have an increased risk of ADE, where reported rates remain low and under-reportin...

OBJECTIVES To determine the association between inappropriate medication use and self-reported adverse drug effects (ADEs). DESIGN Prospective cohort study with three annual mailed surveys. SETTING Population-based sample of Iowa Medicare beneficiaries. PARTICIPANTS Cohort members (n5626) with established mobility disability and complete pharmacy dispensing records, continuous Medicare el...

Overview of Medication Errors and Adverse Drug Events Medication errors (MEs) are the most common type of medical error occurring in the intensive care unit (ICU). The definitions and incidence rates for MEs and types of adverse drug events (ADEs) are listed in Table 1-1. Medication errors may result in patient injury, but this is not a requirement to be considered an error. Clinicians strive t...