Anthrosols known as Amazonian Dark Earth (ADE) have borne witness to the intensification of sedentary patterns and the demographic increase in Central Amazon. As a result, a recurring pattern has been observed of mounds with ADE arising from domestic activities and the disposal of waste. The objective of this research was to demonstrate the relationship of these anthropic activities with pedoge...

The immunopathogenesis of dengue haemorrhagic fever and dengue shock syndrome is thought to be mediated by a variety of host factors. Enhancing antibodies are one of the key regulating molecules. These antibodies, via antibody-dependent enhancement (ADE) of infection, are able to facilitate dengue virus (DENV) growth in Fc-bearing host cells. The mechanism of ADE-enhanced DENV production is bel...

We determined the prevalence of adverse drug events (ADEs) in a general teaching hospital in Rabat, Morocco. We performed a 5-day cross-sectional study of hospital departments recruiting inpatients and outpatients. Among the 1390 patients surveyed, 59 (4.2%) experienced at least 1 ADE and for 20 patients (1.4%) the ADE was responsible for hospitalization or prolongation of hospitalization. The ...

We recently demonstrated that extracellular ATP effectively activates adenosine (Ade) A(2B) receptors indirectly through a localized rapid conversion to Ade by ectonucleotidases on the membrane surface of C6Bu-1 rat glioma cells. These responses were observed even in the presence of adenosine deaminase (ADA). Here, we demonstrate that such responses indeed occur in A(2B) receptor-expressing Xen...

BACKGROUND Marburg virus (MARV) and Ebola virus (EBOV) cause severe hemorrhagic fever in primates. Earlier studies demonstrated that antibodies to particular epitopes on the glycoprotein (GP) of EBOV enhanced virus infectivity in vitro. METHODS To investigate this antibody-dependent enhancement (ADE) in MARV infection, we produced mouse antisera and monoclonal antibodies (mAbs) to the GPs of ...

Adverse events detection is critical in many fields, e.g., adverse drug event (ADE) detection in medical field. ADE is an unexpected and harmful consequence of drug usage. Many researchers found that identifying the correlation between the use of drugs and adverse events from biomedical literature can contribute a lot to drug safety monitoring. In this paper, we propose a novel approach based o...

We use F. Ferrari’s methods relating matrix models to Calabi-Yau spaces in order to explain much of Intriligator and Wecht’s ADE classification of N = 1 superconformal theories which arise as RG fixed points of N = 1 SQCD theories with adjoints. We find that ADE superpotentials in the Intriligator–Wecht classification exactly match matrix model superpotentials obtained from Calabi-Yaus with cor...

Reliable evaluation for the performance of classifiers depends on the quality of the data sets on which they are tested. During the collecting and recording of a data set, however, some noise may be introduced into the data, especially in various real-world environments, which can degrade the quality of the data set. In this paper, we present a novel approach, called ADE (automatic data enhance...

OBJECTIVES To assess Texas pharmacists' knowledge of adverse drug event (ADE) reporting to the Food and Drug Administration (FDA) and to determine demographic and practice characteristics associated with this knowledge. DESIGN Cross-sectional descriptive study. SETTING Austin, TX, in June and July 2009. PARTICIPANTS 377 pharmacists practicing in hospital and community settings. INTERVEN...