نتایج جستجو برای: موش c57bl6
تعداد نتایج: 12966 فیلتر نتایج به سال:
METHODS. Retinal oxygenation response ( PO2) was measured using functional magnetic resonance imaging (MRI) and either carbogen or 100% oxygen inhalation challenge in C57BL/6J control (C) mice. Retinal PO2 during carbogen breathing was also measured in PKC knockout (C57BL6-Prkcb1; [KO]), 4 month C57BL/6J diabetic (D), and 4-month diabetic PKC KO (D KO) mice. Retinal PKC protein expression was a...
Background Oxidative stress (OS), the production of free oxygen radicals caused by for instance renal ischemia/reperfusion injury (IRI), results in age associated diseases and accelerated aging. We have shown that preoperative fasting in young-lean C57BL6 male mice protects against renal IRI [1]. Since human patients are usually older and suffer from (co)morbidities, we investigated the effects...
area burn (C57BL6 mice; n=4 per time point). Imaging of the injured limb and skin incision only contra-lateral limb (control) was performed weekly (1–9 weeks post-injury) in a longitudinal fashion. Acoustic concentration (10*log(mm-3)) was calculated for each ultrasound frame. Houndsfield units were used to calculate HO volume on microCT imaging. Histology was used to confirm the presence of HO...
Signal transducer and activator of transcription (STAT) 4 is one of the seven members of the STAT family. STAT4 has a prominent role in mediating interleukin-12-induced T-helper cell type 1 lineage differentiation. T cells are key players in the maintenance of adipose tissue (AT) inflammation. The role of STAT4 in obesity and AT inflammation is unknown. We sought to determine the role of STAT4 ...
PURPOSE To investigate cardiomyopathy in offspring in a mouse model of pregestational type 1 diabetic pregnancy. METHODS Pregestational diabetes was induced with STZ administration in female C57BL6/J mice that were subsequently mated with healthy C57BL6/J males. Offspring were sacrificed at embryonic day 18.5 and 6-week adolescent and 12-week adult stages. The size and number of cardiomyocyte...
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