Rationale: Cardiac stem cell-derived exosomes have been demonstrated to promote cardiac regeneration following myocardial infarction in preclinical studies. Recent studies have used intramyocardial injection in order to concentrate exosomes in the infarct. Though effective in a research setting, this method is not clinically appealing due to its invasive nature. We propose the use of a targetin...

Combined heat and power (CHP) production is universally accepted as one of the most energy-efficient technologies to produce energy with lower fuel consumption and fewer emissions. In CHP technology, heat and power generation follow a joint characteristic. Traditional CHP production is usually applied in backpressure plants, where the joint characteristic can often be represented by a convex mo...

Although the cost allocation method does not change the total benefits of CHP, the use of various cost allocation methods generally results in significant differences in costs allocated for CHP products. In order to overcome the inadequacy of existing cost allocating methods in theory and in practice, according to the different roles of anergy and exergy in heat supply process of CHP plant, the...

Alternative energy sources, such as biomass CHP plants, have recently gained significantly in importance and action is due both on the large scale corporate level and on the small scale. Hence, making the scope and economic outline of such projects easily intelligible without losing relevant details seems a key factor to further promote the necessary developments. The model setup presented in t...

We report the first evidence of a chromosome-encoded toxin-antitoxin locus in spirochetes. This locus has been found in the pathogenic spirochete Leptospira interrogans and exhibits homologies with the pem/chp loci. The L. interrogans chp locus consists of two genes: chpK (for "killer protein") and its upstream partner chpI (for "inhibitory protein"). Expression of ChpK in Escherichia coli resu...

Sustainable economic development requires the efficient production and use of energy; combined heat and power (CHP) systems contribute to both of these goals. While a recent executive order set a national goal of 40 GW of new industrial CHP by 2020, the deployment of CHP is challenged by financial, regulatory, and workforce barriers. Discrepancies between private and public interests can be min...

Background. Traditional Chinese medicine (TCM) includes Chinese herbal products (CHPs), acupuncture, and traumatology manipulative therapies. TCM physicians often prescribe CHP to treat patients with osteoporosis; however, the drugs used and their patterns of prescriptions have yet to be characterized. This study, therefore, aimed to evaluate the CHP used for the treatment of osteoporosis in Ta...

Long-term production of murine hematopoietic cells in vitro is dependent on establishment of a complex microenvironment consisting of a variety of stromal cells and an extensive extracellular matrix which includes collagen, fibronectin, laminin, proteoglycans, and other undefined components adherent to the culture dishes. Cis-4-hydroxyproline (CHP), a relatively specific inhibitor of collagen s...

This paper presents a novel control algorithm for optimising operational costs of a combined domestic micro-CHP (combined heat and power), battery and heat storage system. Using a minute by minute basic time-step, this work proposes a simple and computationally efficient rule based whole-system management, developed from empirical study of realistic simulated domestic electricity and heat loads...

Austria aims at increasing its share of renewable energy production by 11% until 2020. Combined Heat and Power (CHP) plants fired by forest wood can significantly contribute to attaining this target. However, the spatial distribution of biomass supply and of heat demand limits the potentials of CHP production. This paper assesses CHP potentials using a mixed integer programming model that optim...