The Effect of Chalcone Isomerase (Chi) Gene Silencing on Flavonoids Content in Petunia hybrida using RNAi Technology

RNA interference (RNAi) is a promising strategy to suppress the expression of disease-relevant genes and induce post-transcriptional gene silencing. Their simplicity and stability endow RNAi with great advantages in molecular medicine. Several RNAi-based drugs are in various stages of clinical investigation. This review summarizes the ongoing research endeavors on RNAi in molecular medicine, de...

With siRNA-based drugs becoming established as a therapeutic modality, large companies are engaging in the field through deals and acquisitions, cardiovascular metabolic diseases among their targets.

UNLABELLED Antiviral RNA-mediated silencing (RNA interference [RNAi]) acts as a powerful innate immunity defense in plants, invertebrates, and mammals. In Caenorhabditis elegans, RNAi is systemic; i.e., RNAi silencing signals can move between cells and tissues. Furthermore, RNAi effects can be inherited transgenerationally and may last for many generations. Neither the biological relevance of s...

Numerous genes involved in calcification, algal endosymbiosis, and the stress response have been identified corals by large-scale gene expression analysis, but functional analysis of those is lacking. There are few experimental examples manipulation corals, such as knockdown RNA interference (RNAi). The purpose this study to establish an RNAi method for coral juveniles. As a first trial, encodi...