BACKGROUND The aim of the present paper was to examine the correlation between serum concentrations of 12 soluble biological markers and stages of myeloma evaluated according to the Durie-Salmon (D-S) and International Prognostic Index (IPI) stratification systems. METHODS We analyzed a non-pretreated group of 179 patients with MM stratified according to D-S and IPI. Serum levels of soluble b...

High-end graphics processing units (GPUs), such as NVIDIA Tesla/Fermi/Kepler series cards with thousands of cores per chip, are widely applied to high-performance computing fields in a decade. These desktop GPU cards should be installed in personal computers/servers with desktop CPUs, and the cost and power consumption of constructing a GPU cluster platform are very high. In recent years, NVIDI...

This paper presents new and ongoing development efforts directed toward open-source, cross-platform C++ “tools” for music and audio programming. RtMidi provides a common application programming interface (API) for realtime MIDI input and output on Linux, Windows, Macintosh, and SGI computer systems. RtAudio provides complementary functionality for realtime audio input and output streaming. The ...

The research presented in this report focuses on the spacecraft simulators, Whorl-I and Whorl-II, in the Space Systems Simulation Laboratory (SSSL) at Virginia Tech. The goal of this research is to develop a program to visualize the attitude of the simulators in real-time through Analytical Graphics Inc.’s Systems Tool Kit (STK). Spacecraft missions are high-risk and highexpense; therefore, ext...

The tomato Pto gene, which encodes a serine/threonine kinase (STK) domain-containing protein, confers resistance to bacterial speck disease caused by Pseudomonas syringae pv. tomato (Pst). In this study, in vivo recognition assays using PVX constructs showed that AvrPto was specifically recognized in the pepper genotypes. This AvrPto recognition caused a nonhost hypersensitive response (HR) and...

A previous study demonstrated that proximal tubule cells regulate HCO(3)(-) reabsorption by sensing acute changes in basolateral CO(2) concentration, suggesting that there is some sort of CO(2) sensor at or near the basolateral membrane (Zhou Y, Zhao J, Bouyer P, and Boron WF Proc Natl Acad Sci USA 102: 3875-3880, 2005). Here, we hypothesized that an early element in the CO(2) signal-transducti...

The cell cycle and the circadian clock communicate with each other, resulting in circadian-gated cell division cycles. Alterations in this network may lead to diseases such as cancer. Therefore, it is critical to identify molecular components that connect these two oscillators. However, molecular mechanisms between the clock and the cell cycle remain largely unknown. A model filamentous fungus,...

Sivil Toplum Kuruluşları (STK), uyum faaliyetlerinin gerçekleşmesi adına önemli bir rol üstlenmektedir. Bu faaliyetlerin yürütülmesi esnasında, ihtiyaçların tespitinden, karşılanmasına kadarki tüm süreçlerde birtakım sorunlar yaşanabilmektedir. nedenle bu çalışma, göçmen gruplarla çalışan STK yetkililerinin, göçmenlerin sürecine yönelik gerçekleştirdikleri faaliyetler süresince yaşadıkları soru...

It is becoming increasingly clear that macrophages are a diverse and dynamic population of cells that can be activated down a number of distinct developmental pathways (recently reviewed in refs. [1, 2]). These cells have the capacity to perform a wide range of critical functions including the recognition, phagocytosis, and clearance of invading pathogens through the expression of pattern recog...