The effects of carboxyacyl phosphatidylethanolamine derivatives (CA-PE) on the physicochemical properties of liposomes were examined from standpoints of zeta-potential, agglutination, phase transition temperature, microviscosity and micropolarity. Absolute zeta-potential of liposomes containing Succinyl-PE or Glutaryl-PE exceeded that of those containing Dodecanyl-PE. The addition of Succinyl-P...

The interdisciplinary nature of complex design poses the challenge of computational burden due to complexity of the problem. In view of this a design methodology has been proposed in this work. The primary goal of the proposed methodology is to simplify and shorten the design process. Within this work a framework is presented in which modelling, multiobjective optimisation and multi criteria de...

this study was conducted to determine the prevalence of pe in patients with v/q scans interpreted as representing a very low probability (vlp) of pe (1-3 small segmental perfusion defects with a normal chest radiograph). an analysis of the entire data set obtained during the pioped study was performed. of the total of 1,359 patients in whom the presence or absence of pe was confirmed, 80 (6%) p...

background: pre-eclampsia (pe) is a pregnancy associated disorder characterized by hyper-tension and proteinuria. the first 2 stages of pe cause dysfunction in uteroplacental perfusion and oxidative stress while the third stage of pe is due to the release of inflammatory and angiogenic factors, which could lead to maternal endothelial damage and systemic inflammatory response. in this study, we...

Pseudomonas exotoxin A (PE) is one of the most potent cytotoxic agents produced by Pseudomonas aeruginosa. In this study, we examined the possibility of using PE with a deletion of 38 carboxyl-terminal amino acid residues, designated PE(Delta576-613), for active immunization against PE-mediated disease. We first examined the toxic effects of PE and PE(Delta576-613) on 5- and 9-week-old ICR mice...

The effects of a red wine phenolic extract (PE) on plasma lipoproteins and early atherosclerosis were studied in hamsters. Hamsters (n = 32) were divided into 4 groups of 8 and fed an atherogenic diet for 8 wk. They received by force- feeding 7.14 mL/(kg. d) PE in 2.6 mol/L ethanol (E + PE) or PE in water (W + PE), mimicking a moderate consumption of red wine or alcohol-free red wine [30.4 mg/(...

We constructed two chimeric toxins; one composed of epidermal growth factor (EGF) and pseudomonas exotoxin A (PE), designated EGF-PE and the other composed of EGF and PE with a deletion of the Ia domain (cell-binding domain), designated EGF-PE (delta Ia). Both chimeric toxins reacted with anti-EGF and anti-PE antibodies. The cell-killing experiments showed that EGF-PE, but not EGF-PE (delta Ia)...

Background: Lack of sufficient information on the mechanism of plasma exchange (PE) therapy in multiple sclerosis (MS), has limited this treatment to individual patients with severe relapses who have been refractory to other treatments. This is while PE is used very successfully as a first-line standard treatment in many other neuro-immune disorders. Recent data suggest that Treg/Th17 counterb...

The incorporation of several anti-rodent masterbatches into polyethylene (PE) granules used for gas pipes and the effects of the masterbatches on the physical properties of the pipes were studied. Four commercial anti-rodent masterbatches from different international companies including, Clariant, Alchemix, PolyOne, and Newgen were used in this research. Each of the masterbatch was primarily dr...