a relationship between kala-azar and sleepingsickness, and it is natural that any drug which has given good results in cases of sleepingsickness should be tried in kala-azar. Probably the first occasion on which a trypanicidal drug was tried in kala-azar was about the year 1906 when two cases of kalaazar were treated by myself in the Ezra Hospital, Calcutta with a drug called ' arrhenal.' The r...

The treatment of high-risk prostate cancer (HRPCa) is a tremendous challenge for uro-oncologists. The identification of predictive moleculobiological markers allowing risk assessment of lymph node metastasis and systemic progression is essential in establishing effective treatment. In the current study, we investigate the prognostic potential of miR-205 in HRPCa study and validation cohorts, se...

Identifying targets of dysregulated microRNAs (miRNAs) will enhance our understanding of how altered miRNA expression contributes to the malignant phenotype of breast cancer. The expression of miR-205 was reduced in four breast cancer cell lines compared to the normal-like epithelial cell line MCF10A and in tumor and metastatic tissues compared to adjacent benign breast tissue. Two predicted bi...

Cancer chemotherapy can be used depending on the cancer status either alone or in combination with surgery and/or radiotherapy. The effectiveness of chemotherapy in treatment of cancer patients is largely due to the cytostatic and cytotoxic effects of the drugs on tumor cells. Additionally, the cell cycle status of tumor cells is important in determining the effectiveness of chemotherapy becaus...

MicroRNA-205 (miR-205) was revealed as a novel diagnostic and prognostic biomarker for lung cancer, but the results in the published papers were inconsistent. This meta-analysis aimed to investigate the diagnostic and prognostic roles of miR-205 in patients with lung cancer. Totally, 16 eligible articles were included, among which 10 articles investigated the diagnostic value of miR-205, 5 arti...

PURPOSE miR-205 is significantly up-regulated in endometrioid adenocarcinoma. In this study, the significant anticancer effect of a miR-205 inhibitor was investigated in both endometrial carcinoma and progesterone-resistant endometrial carcinoma cells. RESULTS Compared with Ishikawa endometrial cancer cells, miR-205 was expressed at higher levels in a progesterone-resistant (PR) sub-cell line...

OBJECTIVE To determine whether a topical ophthalmic diclofenac sodium formulation containing a proprietary polymeric drug delivery system (ISV-205), when dosed concomitantly with 1% prednisolone acetate, is effective in blocking the intraocular pressure (IOP) response in humans. DESIGN This was a multicenter, prospective, double-masked, parallel, vehicle-controlled study. We included 136 firs...

Multiple lines of evidence indicate that important functional properties are embedded in the non-coding portion of the human genome, but identifying and defining these features remains a major challenge. An initial estimate of the magnitude of functional non-coding DNA was derived from comparative analysis of the first available mammalian genomes (human and mouse), which indicated that fewer th...