BACKGROUND To report our prospective experience on the incidence and pattern of oxaliplatin (OXA)-induced peripheral neuropathy (OXA-IPN) in patients with colorectal cancer (CRC) treated with either FOLFOX-4 or XELoda + OXaliplatin (XELOX). PATIENTS AND METHODS One hundred and fifty patients scheduled to be treated with either FOLFOX or XELOX for CRC were prospectively monitored at baseline a...

Previous research has identified a population of cells throughout the limbic system that discharge as a function of the animal's head direction (HD). Altering normal motor cues can alter the HD cell responses and disrupt the updating of their preferred firing directions, thus suggesting that motor cues contribute to processing the HD signal. A pathway that conveys motor information may stem fro...

BACKGROUND Inherited peripheral neuropathies (IPN) are the most common inherited neurological condition. It represents a highly heterogeneous group, both clinically and genetically. Targeted disease specific gene panel massively parallel sequencing (MPS) seems to be a useful tool in diagnosis of disorders with high genetic heterogeneity. METHODS In our study, we have designed, validated and u...

Neste artigo mapeamos as práticas cotidianas realizadas no/pelo Instituto de Pesquisa e Memória Pretos Novos (IPN) que produzem articulam um conjunto conhecimentos, narrativas arquivos contra-hegemônicos. Nosso argumento principal consiste no entendimento o IPN empreende uma reparação reescrita da memória afrodiaspórica, conforme suas se dão em movimentos transversais existência negra como form...

The preceding companion study (Eckenrode et al., 1992) showed that cell suspension transplants of fetal habenula cells placed near the interpeduncular nucleus (IPN) following lesions of the fasciculus retroflexus (FR) restore the normal pattern of substance P (SP) staining in habenular target subnuclei of the IPN in both perinatal and adult hosts, and restore ChAT staining in the IPN of perinat...

Repeated exposure to drugs of abuse can produce adaptive changes that lead to the establishment of dependence. It has been shown that allelic variation in the α5 nicotinic acetylcholine receptor (nAChR) gene CHRNA5 is associated with higher risk of tobacco dependence. In the brain, α5-containing nAChRs are expressed at very high levels in the interpeduncular nucleus (IPN). Here we identified tw...

M. I. Neria-González, A. R. Domínguez-Bocanegra, J. Torres, R. Maya-Yescas, and R. Aguilar-López a Departamento de Biotecnología y Bioingeniería, CINVESTAV-IPN bDepartamento de Control Automático, CINVESTAV-IPN Av. Instituto Politécnico Nacional 2508, San Pedro Zacatenco, México, D.F. Mexico c Facultad de Ingeniería Química, Universidad Michoacana de San Nicolás de Hidalgo, Santiago Tapia 403, ...

BACKGROUND AND PURPOSE Nicotinic acetylcholine receptors (nACh receptors) play a central role in the habenulo-interpeduncular system. We studied nicotine-induced release of NA and ACh in the habenula and interpeduncular nucleus (IPN). EXPERIMENTAL APPROACH The habenula and IPN were loaded with [(3) H]-choline or [(3) H]-NA and placed in superfusion chambers. [(3) H]-ACh release was also stimu...

Studies were conducted to evaluate uterine motility and fertility of ova in ewes either given or not given supplemental selenium/vitamin E (SSE or NSE, respectively). The ewes were maintained on either an adequate plane of nutrition (APN) or an inadequate plane of nutrition (IPN). In a fertility study, 60 ewes were allotted to four treatment groups, (15 ewes per group): SSE-APN, NSE-APN, SSE-IP...