A prevalent new field canine parvovirus type-2a (CPV-2a) strain, CPV-s5, was isolated from the feces of a dog with diarrhea in Shenzhen, China. The genome of CPV-s5 was determined and analyzed, which will facilitate further study of the molecular epidemiology and genetic diversity of CPV-2 field isolates in southern China.

Feline panleukopenia virus (FPV) and its host range variant, canine parvovirus (CPV), can bind the feline transferrin receptor (TfR), while only CPV binds to the canine TfR. Introducing two CPV-specific changes into FPV (at VP2 residues 93 and 323) endowed that virus with the canine TfR binding property and allowed canine cell infection, although neither change alone altered either property. In...

Understanding the mechanisms of cross-species virus transmission is critical to anticipating emerging infectious diseases. Canine parvovirus type 2 (CPV-2) emerged as a variant of a feline parvovirus when it acquired mutations that allowed binding to the canine transferrin receptor type 1 (TfR). However, CPV-2 was soon replaced by a variant virus (CPV-2a) that differed in antigenicity and recep...

Despite of the role of domestic dogs as reservoirs for threatening viral diseases for wild carnivores, few studies have focused to identify circulation of viruses among dogs living in human/wildlife interfaces. To identify canine parvovirus (CPV) types circulating in dogs living in an Atlantic forest biome, faecal samples (n = 100) were collected at the same period (one week) corresponding to e...

Canine parvovirus-2 (CPV-2) has been considered to be an important pathogen of domestic and wild canids and has spread worldwide since its emergence in 1977. It has been reported from Asia, Australia, New Zealand, the Americas and Europe. There are two distinct parvoviruses known to infect dogs the pathogenic CPV-2 and CPV-1 or the canine minute virus (CnMV). The disease caused by CPV-2 is char...

Canine parvovirus (CPV) is highly contagious and causes acute hemorrhagic gastroenteritis in puppies. Four variants of CPV-2 are widely distributed worldwide: CPV-2, CPV-2a, CPV-2b, CPV-2c. However, there have been few molecular characterization studies CPV-2a circulating dog populations South Korea. Here, we isolated characterized two CPVs: the CPV2101 CPV2102 isolates. They were confirmed to ...

Rapid immunochromatography test (RICT) kits are commonly used for the diagnosis of canine parvovirus (CPV) because their rapid turnaround time, simplicity, and ease use. However, potential cross-reactivity low sensitivity can yield false-positive or false-negative results. There 4 genotypes CPV. Therefore, evaluating performance reliability RICT CPV detection is essential to ensure accurate app...

Orthopoxviruses evade host immune responses by using a number of strategies, including decoy chemokine receptors, regulation of apoptosis, and evasion of complement-mediated lysis. Different from other poxviral subfamilies, however, orthopoxviruses are not known to evade recognition by CTL. In fact, vaccinia virus (VV) is used as a vaccine against smallpox and a vector for eliciting strong T ce...

Canine parvovirus (CPV) reproduces by co-opting the resources of host cells, inevitably causing cytotoxic effects to the host cells. Feline kidney F81 cells are sensitive to CPV infection and show disparate growing statuses at different time points post-infection. This study analysed the response of F81 cells to CPV infection at successive infection time points by iTRAQ-based quantitative prote...

Canine parvovirus-2 (CPV-2) is a highly contagious and key enteropathogen affecting the canine population around globe by causing parvoviral enteritis (CPVE) vomition. CPVE one of leading causes morbidity mortality in puppies young dogs. Over years, five distinct antigenic variants CPV-2, namely CPV-2a, CPV-2b, new CPV-2c, have emerged throughout world. CPV-2 infects diverse range wild animals,...