There are multiple reasons why anisotropic basis functions may be needed or be more appropriate. The most obvious is that if the basis function is to be defined on Rn × T then there is no natural norm on this space that would reflect the unique properties of time. A second reason is that function being interpolated or approximated may incorporate a directional dependence. Thirdly, differentiabi...

The implementation of implicit Runge{Kutta methods requires the solution of large systems of non-linear equations. Normally these equations are solved by a modiied Newton process, which can be very expensive for problems of high dimension. The recently proposed triangularly implicit iteration methods for ODE-IVP solvers 5] substitute the Runge{Kutta matrix A in the Newton process for a triangul...

Running title: Combination of ABT-199 and ibrutinib for CLL

The ant colony optimization (ACO) algorithm is a new heuristic algorithm that offers good robustness and searching ability. With in-depth exploration, the ACO algorithm exhibits slow convergence speed, and yields local optimization solutions. Based on analysis of the ACO algorithm and the genetic algorithm, we propose a novel hybrid genetic ant colony optimization (NHGAO) algorithm that integra...

لایه کَندگی کربن‌­چگالی‌­بالا یکی از گزینه‌­های امیدبخش در افروزش گرماهسته­‌ای هدف­‌های گداخت محصورشدگی لختی است. به منظور کاهش ناپایداری‌­های هیدرودینامیکی و هم‌­چنین حفظ سوخت پدیده پیش‌­گرمایش، طراحی دوتایی با بیرونی کربن­‌چگالی­‌بالا که اخیراً توسط محققین مورد توجه قرار گرفته است، استفاده شده این‌­رو این پژوهش، بهینه‌­سازی یک هدف کروی دلخواه تک پلی‌­استایرن را کد MULTI-IFE بررسی دادیم. هدف، تح...

Cure rates for acute myeloid leukemia (AML) remain suboptimal; thus new treatment strategies are needed for this deadly disease. Poor clinical outcomes have been associated with overexpression of the anti-apoptotic Bcl-2 family proteins Bcl-2, Bcl-xL, and Mcl-1, which have garnered great interest as therapeutic targets. While the Bcl-2-selective inhibitor ABT-199 has demonstrated promising prec...

A monoclonal antibody (mAb) (T-199) of IgG1 isotype was raised against medulloblastoma by immunizations of mice with the medulloblastoma cell line TE-671. Studies of the specificity of mAb T-199 on cell lines as well as fresh frozen sections of normal and malignant tissues revealed the antigen in high amounts on the cell surface of neuroectodermally derived tumors such as medulloblastoma, neuro...