The Kuhn-Tucker model of Wales and Woodland (1983) provides a utility theoretic framework for estimating preferences over commodities for which individuals choose not to consume one or more of the goods. Due to the complexity of the model, however, there have been few applications in the literature and little attention has been paid to the problems of welfare analysis within the Kuhn-Tucker fra...

Acute promyelocytic leukaemia (APML) is a biologically and clinically distinct variant of AML, currently classified as acute myeloid leukaemia with recurrent cytogenetic anomalies t(15;17) (q22;q21), promyelocytic leukaemia-retinoic acid receptor alpha, diagnosis regardless of blast count in the World Health Organization classification system. It is one of the curable malignancies, has a unique...

Refractory anemia with ring sideroblasts associated with marked thrombocytosis (RARS-T) is a hematological malignancy that combines features of both a myeloproliferative and myelodysplastic disorder. There have been recent reports of the successful treatment of anemia in 2 patients with RARS-T with lenalidomide. Here we report the successful treatment of massive splenomegaly in a patient with a...

We empirically investigate the effect of the payment mechanism on contingent values by asking a willingness-to-pay question with one of three different payment mechanisms: individual contribution, contribution with provision point, and referendum. We Ž nd statistical evidence of more afŽ rmative responses in the referendum treatment relative to the individual contribution treatment, some weak s...

Rock climbers are likely to exhibit preference heterogeneity dictating the way with which such sport is practiced. This has a reflection on the population’s structure of recreational values of rock-climbing destinations, their attributes, and to land management policies. We test this hypothesis on a panel of destination choices by a sample of members of the Italian Alpine Club. Using a latent-c...

Natural Resource Damage Assessment cases often call for compensation in nonmonetary or restoration equivalent terms. In this article, we present an approach that uses a conventional economic model, a travel cost random utility model of site choice, to determine compensatory restoration equivalents for hypothetical beach closures on the Gulf Coast of Texas. Our focus is on closures of beaches on...

This analysis breaks down the congestion levels experienced during specific parts of a wilderness canoe trip. By explicitly addressing the heterogeneity in preferences for congestion during a trip, we are able to determine the relative value canoeists place on solitude at different points of a trip. Our econometric model utilizes a random effects probit framework to efficiently estimate the wel...

A hybrid stated-preference model is presented that combines the referendum contingent valuation response format with an experimentally designed set of attributes. A sequence of valuation questions is asked to a random sample in a mailout mail-back format. Econometric analysis shows greater discrimination between alternatives in the final choice in the sequence, and the vector of preference para...

A highly polymorphic locus associated with the variable tandem repetition of a 35 bp consensus sequence was mapped to chromosome 10, band q26. Examination of leukocyte DNA from a cancer patient revealed the twenty-fold amplification of one allelic fragment of this locus, while the other allelic fragment demonstrated a normal copy number. In another patient, Southern blotting of leukocyte DNA de...

By the methods of bioinformatics, the sequences of HCV E2 protein from all the genotypes are studied on the variation and the B-cell epitopes. We find that even in the HVR1 and HVR2 regions, there are also some conservative sites, such as T2, G6, G23, and Q26, all of which belong to polar R-base amino acids without charge, and can lost proton to conform hydrogen bond. Meanwhile, we find the con...