Im vielen Umfeldern wird in zunehmendem Maße gefordert, für Produkte nicht nur bei Projektabschluss, sondern über deren gesamte Lebensdauer hinweg ihre Kompatibilität mit den Anforderungen zu gewährleisten. Requirements Engineering (RE) ist in solchen Umfeldern als ein integraler Bestandteil des Product Lifecycle Managements (PLM) zu realisieren. Der Beitrag stellt einige Konzepte des PLM vor u...

Companies that collaborate within the product development processes need to implement an effective management of their collaborative activities. Despite the implementation of a PLM system, the collaborative activities are not efficient as it might be expected. This paper presents an analysis of the problems related to the collaborative work using a PLM system, identified through a survey. From ...

This paper introduces a model of the information flows in Product Life cycle Management (PLM), serving as the basis for understanding the role of standards in PLM support systems. Support of PLM requires a set of complementary and interoperable standards that cover the full range of aspects of the products’ life cycle. The paper identifies a typology of standards relevant to PLM support that ad...

Post-polio syndrome (PPS) in individuals with polio longer than 15 years is characterized by weakness and/or muscle fatigue, deficit of deglutition and breath and periodic limb movements (PLM) during sleep. We undertook a review of 99 patients with PPS, and assessed the frequency of PLM through polysomnographic recordings at our sleep disorders unit. The total number of PLM, total time of sleep...

Despite intensive investigation of molecular mechanisms underlying the pathogenesis of sepsis, many aspects of sepsis remain unresolved; this hampers the development of appropriate therapeutics. In the present study, we developed a biologic nanomedicine containing a cationic antimicrobial decapeptide KSLW (KKVVFWVKFK), self-associated with biocompatible and biodegradable PEGylated phospholipid ...

This paper presents and discusses an analysis of the industrialization and production steps within the Product Life cycle Management (PLM) context. Initially, PLM was focused almost exclusively on the product design, but nowadays, it tends to cover all the steps of the product life cycle. In the same time, the industrialization and the production are not sufficiently integrated into the PLM sol...

The product lifecycle management (PLM) system has a significant role to support the collaboration and manage the partnership between OEM and Supplier to enable the success of supplier integration. Today great rates of cooperation as suppliers have been dedicated to SMEs. Since one of the PLM task is to control the collaboration between OEM and suppliers, this paper provide supplier (SMEs) a fra...

This paper presents an approach of knowledge capitalization within a PLM (Product Lifecycle Management) system. We propose a methodology which allows knowledge integration through a PLM system. Knowledge integration is realized during the deployment of the PLM system and the processes definition stage. This paper is illustrated by an industrial example in the plastics industry.

Intracellular [Na] is approximately 3 mmol/L higher in heart failure (HF; in our arrhythmogenic rabbit model), and this can profoundly affect cardiac Ca and contractile function via Na/Ca exchange and Na/H exchange. Na/K-ATPase is the primary mechanism of Na extrusion. We examine here in HF rabbits (and human hearts) expression of Na/K-ATPase isoforms and phospholemman (PLM), a putative Na/K-AT...

Cardiac sympathetic stimulation activates beta-adrenergic (beta-AR) receptors and protein kinase A (PKA) phosphorylation of proteins involved in myocyte Ca regulation. The Na/K-ATPase (NKA) is essential in regulating intracellular [Na] ([Na]i), which in turn affects [Ca]i via Na/Ca exchange. However, how PKA modifies NKA function is unknown. Phospholemman (PLM), a member of the FXYD family of p...