Microorganisms may persist in the root canal system after therapy (RCT). The purpose of this study was to explore metronidazole (MTR)- and chlorhexidine (CHX)-loaded hydrogels as potential application intracanal medicaments for disinfection. Ultraviolet cross-linked (gGels) were synthesized by GelMA solution photoinitiator, which loaded with MTR (MTR@gGels) CHX (CHX@gGels). gGels, MTR@gGels CHX...

BACKGROUND Methionine synthase (MS) catalyzes the folate-dependent remethylation of homocysteine to methionine. We tested the hypothesis that deficiency of MS impairs endothelial function in mice heterozygous for disruption of the Mtr gene, which encodes MS. METHODS AND RESULTS Plasma total homocysteine was similar in wild-type (Mtr(+/+)) and heterozygous (Mtr(+/-)) mice fed a control diet (4...

OBJECTIVES To establish whether magnetisation transfer ratio (MTR) histograms are sensitive to change in normal appearing grey matter (NAGM) in early relapsing-remitting multiple sclerosis (RRMS) in the absence of significant disability; and to assess whether grey or white matter MTR measures are associated with clinical measures of impairment in early RRMS METHODS: 38 patients were studied (me...

Background:Numerous studies have focused on the association of methionine synthase (MS) A2756G polymorphism and acute hematological cancer risk. However, the results remain inconsistent. Therefore, a meta-analysis was performed to derive a more precise estimate of the association between them. Methods: This meta-analysis involved 25 articles (26 studies) including 8641 hematological cancer pati...

OBJECTIVE To evaluate the efficiency of single-tablet regimens (STR) and multiple-tablet regimens (MTR) with exactly the same or different components. METHODS A study was conducted on HIV-1-infected antiretroviral-naïve patients from 6 Spanish or French centers, who were started on treatment with STR-Atripla®, or the same components separately (MTR-SC), or a different MTR (MTR-Other). Effecti...

BACKGROUND AND PURPOSE Alzheimer disease (AD) is accompanied by macroscopic atrophy on volumetric MR imaging. A few studies have also demonstrated reduction in magnetization transfer ratio (MTR), suggesting microstructural changes in remaining brain tissue. This study assessed the value of measuring MTR in addition to volumetric MR in differentiating patients with AD from control subjects. MA...

mtr mutants of Neurospora crassa are resistant to the amino acid analogs Ty-tethyl-tryptophan (4MT) and para-fluorophenylalanine (FPA) . It has been suggested that the mtr locus is the structural gene for a permease which facilitates the uptake of aromatic amino acids (LESTER 1966; STADLER 1966). The products of forward mutation at mtr can be selected on media supplemented with either 4MT ar FP...

BACKGROUND AND PURPOSE Chronic hypoperfusion may cause ischemic insult in the deep white matter. The magnetization transfer phenomenon is associated with the amount and constitution of myelin. The purpose of this study was to assess the usefulness of the magnetization transfer ratio (MTR) for detecting vasculometabolic abnormalities on positron emission tomography (PET) studies in patients with...

This study used quantitative MRI to study normal appearing white matter (NAWM) in patients with clinically isolated syndromes suggestive of multiple sclerosis and relapsing-remitting multiple sclerosis (RRMS). This was done at ultrahigh field (7 T) for greater spatial resolution and sensitivity. 17 CIS patients, 11 RRMS patients, and 20 age-matched healthy controls were recruited. They were sca...