نتایج جستجو برای: ژن pgc1α
تعداد نتایج: 16210 فیلتر نتایج به سال:
Cancer cells tend to utilize aerobic glycolysis even under normoxic conditions, commonly called the "Warburg effect." Aerobic glycolysis often directly correlates with malignancy, but its purpose, if any, in metastasis remains unclear. When wild-type KISS1 metastasis suppressor is expressed, aerobic glycolysis decreases and oxidative phosphorylation predominates. However, when KISS1 is missing ...
In cardiac ischemia-reperfusion injury, reactive oxygen species (ROS) generation and upregulation of the hypoxia-inducible protein BNIP3 result in mitochondrial permeabilization, but impairment in autophagic removal of damaged mitochondria provokes programmed cardiomyocyte death. BNIP3 expression and ROS generation result in upregulation of beclin-1, a protein associated with transcriptional su...
Milk fat globule membrane (MFGM) comprises carbohydrates, membrane-specific proteins, glycoproteins, phospholipids, and sphingolipids. We evaluated the effects of MFGM consumption over a 12-wk period on endurance capacity and energy metabolism in BALB/c mice. Long-term MFGM intake combined with regular exercise improved endurance capacity, as evidenced by swimming time until fatigue, in a dose-...
Parkinson's disease (PD) is characterized by loss of A9 dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). An association has been reported between PD and exposure to mitochondrial toxins, including environmental pesticides paraquat, maneb, and rotenone. Here, using a robust, patient-derived stem cell model of PD allowing comparison of A53T α-synuclein (α-syn) mutant cells ...
RAP1 is part of shelterin, the protective complex at telomeres. RAP1 also binds along chromosome arms, where it is proposed to regulate gene expression. To investigate the nontelomeric roles of RAP1 in vivo, we generated a RAP1 whole-body knockout mouse. These mice show early onset of obesity, which is more severe in females than in males. Rap1-deficient mice show accumulation of abdominal fat,...
Background and aims: Postmenopausal is associated with heart and metabolic disorders. Although the beneficial role of physical activity and antioxidants in human health has been reported; However, the interactive effects of Aerobic training (AT) and Propolis (Pr) on mitochondrial biogenesis in cardiac tissue is not well understood. The aim of this study was to investigate the effect of eight we...
هدف از این پژوهش، تعیین اثر مکمل کوئرستین در دوران بیتحرکی بر مسیر سیگنالینگ 1PGC- است. همچنین محققان در پی پاسخگویی به این پرسش هستند که آیا مصرف مکمل کوئرستین، میتواند در پیشگیری از آتروفی در دوران بیتحرکی مفید باشد؟ در این پژوهش، 30 سر موش نر صحرایی 2 ماهه نژاد اسپراگداولی (وزن=80/11±295 گرم) انتخاب شدند و در دو گروه کنترل (6n=) و تمرین (24n=) قرار گرفتند. تمرین تناوبی با ش...
Background: We recently reported that treatment with rhBDNF (recombinant human brain-derived neurotrophic factor) improved the reduced exercise capacity of mice heart failure (HF) after myocardial infarction (MI). Since BDNF is to enhance fatty acid oxidation, we herein conducted an in vivo investigation determine whether improvement due enhancement oxidation skeletal muscle via AMPKα-PGC1α (ad...
The Diabetes Control and Complications Trial (DCCT) involved intensive diabetes therapy of subjects with type 1 diabetes mellitus (T1DM) for an average period of 6.5 years. A subset of these subjects gained excessive weight. We tested for association of polymorphisms in 8 candidate genes with the above trait. We found the Gly482Ser polymorphism in the peroxisome proliferator-activated receptor ...
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