Acknowledgments I am grateful for the supervision of Dr. Vijaya Ramachandran during my undergraduate research. I have learned from her the fundamentals of theoretical Computer Science and the joy of doing research. Her tireless passion and motivation enlightens my way through many difficult problems. It is my honor to work with Dr. Ganeshkumar Ganapathy and Rezaul Chowdhury, with generous help ...

ii ACKNOWLEDGMENTS I dedicate my work to my parents Mr. Nageswara Rao and Mrs. Vijaya Lakshmi, my brother and sister-in law Mr. Sapta Nag and Mrs. Parimala and my grandparents Mr. Gandhi and Mrs. Sambrajam for their constant support and encouragement throughout my life. I am very grateful to my advisor Dr. A. Srivastava for his guidance, patience and understanding throughout this work. His sugg...

Superimposed epitopes, in which a shorter epitope is embedded within a longer one, can be presented by the same HLA class I molecule. CD8(+) CTL responses against such epitopes and the contribution of this phenomenon to immune control are poorly characterized. In this study, we examined HLA-A*24:02-restricted CTLs specific for the superimposed HIV Nef epitopes RYPLTFGWCF (RF10) and RYPLTFGW (RW...

In the last talk of this conference, Joanne Walters-Wayland will discuss a continuum of minimizable properties of sublocales of a (completely regular) locale. By that is meant a property P such that above any dense sublocale S of a locale L there is a least sublocale having property P. Such properties induce a contraction of the lattice of prenuclei of the frame, i.e., an order-preserving map w...

Acknowledgements This Habilitation thesis presents my work of the last 5 years, mostly done at ETH Zurich and partly at University College London. This was a really exciting time, and I owe a great deal of gratitude to my numerous colleagues and friends. Price: For his friendship and inspiring discussions, both scientific and personal. David's style (best described as " light-hearted wisdom ") ...

Introduction Two large paediatric studies are currently underway in the U.S. to investigate efficacy and safety of MP29-02 (Dymista) in children, with a view to extending its indication to those aged ≥6 yrs. In line with FDA recommendations, these studies compare MP29-02 to placebo. To mimic the clinical trial design of these on-going pediatric studies, this meta-analysis assessed all data avai...

The immatures stages of 8 of the 11 genera (Amastris Stål, Bajulata Ball, Erosne Stål, Harmonides Kirkaldy, Idioderma Van Duzee, Neotynelia Creão-Duarte & Sakakibara, Tynelia Stål, and Vanduzea Goding) of the tribe Amastrini are described for the first time along with brief diagnoses of Membracidae and the subfamily Smiliinae. A key to genera and notes on biology are provided. Multiple species ...

Background GSK is investigating an autologous TCR T-cell therapy for solid tumors that recognizes the cancer testis antigen, NY-ESO-1, presented on cell surface by specific HLA-A*02 sub-types. The aim of this study was to estimate number patients in US 2020 with genotype subtypes HLA-A*02:01, 02:05, 02:06 across selected types (invasive lung, ovarian, gastric, esophageal, invasive and in-situ b...