AMPK is a physiological cellular energy sensor that is activated by phosphorylation at Thr172 in response to changes in cellular ATP levels. AMPK has been recognized as an important upstream signaling intermediate intimately involved in the regulation of the mTOR pathway [1]. AMPK responds to energy stress by suppressing cell growth and biosynthetic processes, in part through its inhibition of ...

Diabetes is associated with beta cell mass loss and islet dysfunctions. mTORC1 regulates beta cell survival, proliferation and function in physiological and pathological conditions, such as pregnancy and pancreatectomy. Here we show that deletion of Raptor, which is an essential component of mTORC1, in insulin-expressing cells promotes hypoinsulinemia and glucose intolerance. Raptor-deficient b...

This paper exploits Application Layer Forward Error Correction (AL-FEC) based on Raptor codes to achieve for reliable video multicast over 802.11n multiple-input multipleoutput (MIMO) channels. The system performance and cross-layer optimisation parameters are analysed for spatial multiplexing (SM) waveforms under different channel conditions and quality of service requirements. Results show th...

The RAPid Telescopes for Optical Response (RAPTOR) system at Los Alamos National Laboratory observed GRB 060206 starting 48.1 minutes after γ-ray emission triggered the Burst Alert Telescope (BAT) on-board the Swift satellite. The afterglow light curve measured by RAPTOR shows a spectacular re-brightening by ∼1 mag about 1 h after the trigger and peaks at R ∼ 16.4 mag. Shortly after the onset o...

Protein three-dimensional structure prediction through threading approach has been extensively studied and various models and algorithms have been proposed. In order to further explore ways to improve accuracy and efficiency of the threading process, this paper investigates the effectiveness of a new method: protein threading via linear programming. Based on the contact map model of protein 3D ...

We are interested in the analysis and optimization of Raptor codes under a joint decoding framework, that is, when the precode and the fountain code exchange soft information iteratively. We develop an analytical asymptotic convergence analysis of the joint decoder, derive an optimization method for the design of efficient output degree distributions, and show that the new optimized distributio...

Myogenesis is an important process during both development and muscle repair. Previous studies suggest that mTORC1 plays a role in the formation of mature muscle from immature muscle precursor cells. Here we show that gene expression for several myogenic transcription factors including Myf5, Myog and Mef2c but not MyoD and myosin heavy chain isoforms decrease when C2C12 cells are treated with r...

In this dissertation we present new methods for designing efficient Raptor codes in finite and practical block lengths. First we propose an extension of Raptor codes which keeps all the desirable properties, including the linear complexity of encoding and decoding per information bit, and improves the performance in terms of the reception rate. Our simulations show a 10% reduction in the requir...

OBJECTIVE Tetrameric α(2)-macroglobulin (α(2)M), a plasma panproteinase inhibitor, is activated upon interaction with a proteinase, and undergoes a major conformational change exposing a receptor recognition site in each of its subunits. Activated α(2)M (α(2)M*) binds to cancer cell surface GRP78 and triggers proliferative and antiapoptotic signaling. We have studied the role of α(2)M* in the r...

یکی از پارامترهای مهم محیط­های پخش نوترون، طول نوترون حرارتی است. روش مرسوم محاسباتی استفاده کد MCNP برمبنای توزیع شار در محیط و برازش تابع ریاضی مربوطه بر آن این پژوهش، روشی نوین که مبنای کارت PTRAC است، ارایه شده پارامتر برای آب­سبک اساس روش­های فوق محاسبه با مقادیر گزارش مراجع مقایسه گردیده تطابق خوبی نیز مشاهده حسن فوق، عدم نیاز به علاوه فرض می­شود تا محل چشمه، فاصله­ی کافی وجود دارد. مسأله...