Comprehensive assessment of cellular responses to the RTS,S/AS01E vaccine is needed to understand potential correlates and ultimately mechanisms of protection against malaria disease. Cellular responses recognizing the RTS,S/AS01E-containing circumsporozoite protein (CSP) and Hepatitis B surface antigen (HBsAg) were assessed before and 1 month after primary vaccination by intracellular cytokine...

Encapsulation of soluble protein antigens in liposomes was previously shown to result in processing of antigen via the major histocompatibility complex class I pathway, as evidenced by costaining of the trans-Golgi region of murine bone marrow-derived macrophages (BMs) by fluorophore-labeled liposomal antigen and by a trans-Golgi-specific fluorescent lipid. Evidence is presented here that free ...

Conjointly conceived by an archivist at the Radio Télévision Suisse (RTS, French speaking PSB) and two media historians, this paper aims discussing diversity of uses digitised AV heritage in Switzerland through lenses their professional experience. It focuses on RTS as a particularly productive case study since has not only been pioneer digitising promoting its holdings to broader audience, but...

Root systems consist of different root types (RTs) with distinct developmental and functional characteristics. RTs may be individually reprogrammed in response to their microenvironment to maximize adaptive plasticity. Molecular understanding of such specific remodeling--although crucial for crop improvement--is limited. Here, RT-specific transcriptomes of adult rice crown, large and fine later...

BACKGROUND The Plasmodium falciparum pre-erythrocytic stage candidate vaccine RTS,S is being developed for protection of young children against malaria in sub-Saharan Africa. RTS,S formulated with the liposome based adjuvant AS01(E) or the oil-in-water based adjuvant AS02(D) induces P. falciparum circumsporozoite (CSP) antigen-specific antibody and T cell responses which have been associated wi...

OBJECTIVE To analyze the performance of Advanced Life Support care mode (ALS) applied to car crash victims using indicators by means of the Revised Trauma Score (RTS) in prehospital phase. METHODS It were analyzed 643 reports of car crash victims cared by public ALS services that occurred in highways of the city of São Paulo, from April 1999 to April 2000. Time intervals assessed were: respon...

Malaria masih endemik di dunia. Data WHO tahun 2020 mencatat 241 juta kasus malaria Rekomendasi vaksin oleh diharapkan dapat membantu menurunkan angka penderita hingga 90% pada 2030 dari baseline 2015. is still a world endemic. According to data, there are million cases of in the world. The vaccine recommendation expected help reduce by from 2015 baseline.

This paper uses neuroevolution of augmenting topologies to evolve control tactics for groups of units in realtime strategy games. In such games, players build economies to generate armies composed of multiple types of units with different attack and movement characteristics to combat each other. This paper evolves neural networks to control movement and attack commands, also called micro, for a...

OBJECTIVE To assess among seriously injured accident victims whether change of the Triage Revised Trauma Score (T-RTS) between first assessment and arrival at the hospital independently predicts mortality. DESIGN Prospective cohort study. METHODS The study analysed data on 507 trauma patients with multiple injuries and with a Hospital Trauma Index-Injury Severity Score (HTI-ISS) of 16 or hi...