P a t i e n t s 16 588 patients who were ≥ 18 years of age (mean age 61 y, 75% men) and had continuous symptoms of chest discomfort for ≥ 30 minutes and < 6 hours from onset to the time of randomization, and electrocardiographic criteria of ST-elevation MI or new left bundle-branch block. Exclusion criteria were planned catheter-based reperfusion; active bleeding or a noncompressible vascular p...

We compare a new R = 120, 000 spectrum of PG 1634 + 706 (zQSO = 1.337, mV = 14.9) obtained with the HDS instrument on Subaru to a R = 45, 000 spectrum obtained previously with HIRES/Keck. In the strong Mg ii system at z = 0.9902 and the multiple cloud, weak Mg ii system at z = 1.0414, we find that at the higher resolution, additional components are resolved in a blended profile. We find that tw...

OBJECTIVE To evaluate the cost-effectiveness of implantable cardioverter defibrillators (ICDs), cardiac resynchronisation therapy pacemakers (CRT-Ps) and combination therapy (CRT-D) in patients with heart failure with reduced ejection fraction based on a range of clinical characteristics. METHODS Individual patient data from 13 randomised trials were used to inform a decision analytical model...

Correspondence to: Dr Anne E Price, Linden House, Wennington Road, Abbots Ripton, Cambridgeshire, PE29 2LP, UK; anne.price@ hinchingbrooke.nhs.uk _________________________ H eart disease is common both in the population at large but also in the population of working age. It is estimated that heart disease, including stroke and high blood pressure, is responsible for more costs than any other di...

-We present new precise U-Th ages of well-preserved coral specimens collected from the island of Barbados, West Indies, and the atoll of Mururoa, French Polynesia. Our new data confirm the ages attributed to oxygen isotope stage 7 in the framework of the Milankovitch theory (BERGER, 1978; MARTINSON et al., 1987). By using thermal ionization mass spectrometry (TIMS), it is also possible to quant...

The population health effect and cost-effectiveness of implementing intensive blood pressure goals in high-cardiovascular disease (CVD) risk adults have not been described. Using the CVD Policy Model, CVD events, treatment costs, quality-adjusted life years, and drug and monitoring costs were simulated over 2016 to 2026 for hypertensive patients aged 35 to 74 years. We projected the effectivene...

The BRITICE-CHRONO consortium of researchers undertook a dating programme to constrain the timing advance, maximum extent and retreat British–Irish Ice Sheet between 31 000 15 years before present. campaign across Ireland Britain their continental shelves, North Sea included 1500 days field investigation yielding 18 km marine geophysical data, 377 cores sea floor sediments, geomorphological str...