A well-integrated host inflammatory response is essential in maintaining health and fighting against diseases, but pathological inflammation is linked to many ailments. Non steroidal anti-inflammatory drugs (NSAIDs), used to treat inflammation and pain, are among the most commonly prescribed drugs world over to treat both acute and chronic conditions, but its use is hampered by NSAIDs-related a...

Results 31 pts with mutations in MVK were evaluated: 22 had 2 mutations (21 with V377I and 1 other mutation; 1 with V203A/H380R), 9 had only 1 mutation after testing the whole gene (8 with V377I, 1 with I268V). The carrier frequency of V377I in our control Caucasian population is 0.3% (2/739). In contrast, in 344 independent cases of recurrent fever submitted for MVK testing, 8 bore a single co...

Impacted cerumen is a widespread reason that patients visit Introduction: their health care providers. It effects approximately 2-6% of the general population and disproportionately impacts up to 65% of patients over 65. This study compared a new cerumen (earwax) removal product (Solution 1; EOS-002; a glycolic acid/bicarbonate formulation) versus two commercially available products (Solution 2...

A Gram-positive, rod-shaped, non-endospore-forming, mycelium-forming actinobacterium (04-St-002(T)) was isolated from the wall of an indoor environment colonized with moulds. On the basis of 16S rRNA gene sequence similarity studies, strain 04-St-002(T) was shown to belong to the family Pseudonocardiaceae, and to be most closely related to Pseudonocardia antarctica (99.2 %) and Pseudonocardia a...

Tumor-associated macrophages (TAMs) in tumor microenvironment regulate cancer progression and metastases. In breast cancer, macrophage infiltration is correlated with a poor prognosis. While metastatic breast cancer is poor prognostic with a severe mortality, therapeutic options are still limited. In this study, we demonstrate that KSG-002, a new herbal composition of radices Astragalus membran...

Chemoresistance is a major hurdle in the management of patients with epithelial ovarian cancer and is responsible for its high mortality. Studies have shown that chemoresistance is due to the presence of a subgroup of cancer cells with stemness properties and a high capacity for tumor repair. We have developed a library of super-benzopyran analogues to generate potent compounds that can induce ...