This biographical sketch on William Arbuthnot Lane corresponds to the historic text, The Classic: The Operative Treatment of Fractures, available at DOI 10.1007/s11999-009-0860-4 .

We reported that iron influx drives the translational expression of the neuronal amyloid precursor protein (APP), which has a role in iron efflux. This is via a classic release of repressor interaction of APP mRNA with iron-regulatory protein-1 (IRP1) whereas IRP2 controls the mRNAs encoding the L- and H-subunits of the iron storage protein, ferritin. Here, we identified thirteen potent APP tra...

OBJECTIVES The purpose of this study was to assess the biodistribution and toxicity of amphotericin B (AMB) following multiple dose administration of an oral lipid-based formulation (iCo-009). METHODS BALB/c female mice were used. ICo-009 was administered twice daily for 5 days at doses of 2.5-20 mg/kg. Untreated animals, oral vehicle or intravenous Fungizone® (1 or 2 mg/kg) served as control...

Triple reassortant (TR) H3N2 influenza viruses cause varying degrees of loss in egg production in breeder turkeys. In this study we characterized TR H3N2 viruses isolated from three breeder turkey farms diagnosed with a drop in egg production. The eight gene segments of the virus isolated from the first case submission (FAV-003) were all of TR H3N2 lineage. However, viruses from the two subsequ...

Methods A retrospective study was made of 6 consecutive pediatric patients with BD. Inclusion criteria were fulfillment of the classification criteria of the International Study Group for Behçet Disease and onset of uveitis at 16 years of age or younger. The main outcome measures were sex, age at onset of uveitis, the initial symptom of Behcet disease, clinical ocular features, ocular complicat...

XCS and later ZCS are considered as adaptive intelligent controllers for road traffic networks. A simple traffic network simulator is employed and results are presented showing that within this environment both classifier system models are capable of learning reasonable policies. It is concluded that for reasons discussed, ZCS may be the more suitable system for this class of problem. Initial t...

In this note we analyse Noekeon, a 128-bit block cipher submitted to the NESSIE project. It is shown that for six of seven S-boxes which satisfy the design criteria of the Noekeon designers the resulting block ciphers are vulnerable to either a differential attack, a linear attack or both. One conclusion is that Noekeon is not designed according to the wide trail strategy. Also, it is shown tha...