Chronic hepatitis C virus (HCV) infection affects approximately 3 million people in the United States and places tremendous demands on the health care system. As many observers have predicted, the disease burden continues to grow as the infected population ages. In this study, we analyzed inpatient data from the Healthcare Cost and Utilization Project, outpatient data from the National Ambulato...

Microsphere Based Liquid Array 2 3 John R. McQuiston * , R. Jordan Waters, Blake A. Dinsmore, Matthew L. Mikoleit, and 4 Patricia I. Fields 5 Enteric Diseases Laboratory Branch, Division of Foodborne Waterborne and 6 Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. 7 8 9 10 Running Title: Molecular Determination of the H-antigens of Salmonella. 11 Correspond...

We study straight-line drawings of planar graphs with few segments and few slopes. Optimal results are obtained for all trees. Tight bounds are obtained for outerplanar graphs, 2-trees, and planar 3-trees. We prove that every 3-connected plane graph on n vertices has a plane drawing with at most 5n/2 segments and at most 2n slopes. We prove that every cubic 3-connected plane graph has a plane d...

Cellular automata are a class of mathematical systems characterized by discreteness (in space, time, and state values), determinism, and local interaction. Little is known mathematically about automata with nonlinear interaction rules. This paper establishes that certain nonlinear automata on finite lattices may be mapped exactly onto a linear automaton, thus providing an 'exact solution' for t...

We study straight-line drawings of non-planar graphs with few slopes. Interval graphs, co-comparability graphs and AT-free graphs are shown to have have drawings in which the number of slopes is bounded by the maximum degree. We prove that graphs of bounded degree and bounded treewidth have drawings with O(log n) slopes. Finally we prove that every graph has a drawing with one bend per edge, in...

Consider a drawing of a graph G in the plane such that crossing edges are coloured differently. The minimum number of colours, taken over all drawings of G, is the classical graph parameter thickness. By restricting the edges to be straight, we obtain the geometric thickness. By further restricting the vertices to be in convex position, we obtain the book thickness. This paper studies the relat...

We have previously shown pp32 and the retinoblastoma protein interact. pp32 and the retinoblastoma protein are nuclear receptor transcriptional coregulators: the retinoblastoma protein is a coactivator for androgen receptor, the major regulator of prostate cancer growth, while pp32, which is highly expressed in prostate cancer, is a corepressor of the estrogen receptor. We now show pp32 increas...

Most individuals exposed to hepatitis C virus (HCV) become chronically infected and are predisposed to liver disease. The mechanisms underlying viral persistence and disease progression are unknown. A role for the HCV NS5A protein in viral replication and interferon resistance has been demonstrated. To identify mechanisms affected by NS5A, we analyzed the gene expression of Huh7 cells expressin...

PURPOSE To study the association of ARMS2 A69S genotype with the development of exudative age-related macular degeneration (AMD) in the unaffected fellow eye and to estimate the duration until the development of AMD in the second eye. DESIGN Retrospective cohort study. METHODS We retrospectively reviewed 326 patients who had exudative AMD in at least 1 eye, genotyping of ARMS2 A69S, and a m...

Cassava (Manihot esculenta Crantz) is a food plant introduced in Africa from America by the Portuguese in 1558. The objective of this study is to establish cassava origins, production, and utilization in Burkina Faso. The investigation was carried out in the regions of Center West, Cascades, Boucle du Mouhoun, Hauts Bassins, South West, and Center East of Burkina Faso. Eighteen cassava processi...