Although DQA1*0301/DQB1*0302 is the human histocompatibility leukocyte antigen (HLA) class II gene most commonly associated with human type 1 diabetes, direct in vivo experimental evidence for its diabetogenic role is lacking. Therefore, we generated C57BL/6 transgenic mice that bear this molecule and do not express mouse major histocompatibility complex (MHC) class II molecules (DQ8(+)/mII(-))...

BACKGROUND Several studies have demonstrated a fundamental role for the histocompatibility antigens (ie, human leukocyte antigens or HLA) in the susceptibility of, or protection to, type 1 diabetes mellitus (T1DM). However, this has not been adequately studied in racially admixtured populations. OBJECTIVES To assess the frequency of HLA class II (DQA1, DQB1 and DRB1) associated to susceptibil...

The gene frequencies of HLA class II alleles were studied in 95 healthy Lebanese Arab and 72 healthy Bahraini Arab subjects. Our aim was to establish the genetic relationship between Bahraini and Lebanese Arabs in terms of HLA class II gene and haplotype frequencies and to compare these results with frequencies for other countries with populations of Caucasian and non-Caucasian descent. Subject...

Program Manager: Patrick Bradshaw – AFOSR Chemistry and Materials Directorate We are creating a novel multifunctional solar biofuel generating platform by coupling designed protein charge separation constructs with newly developed photonic metamaterials – metal/dielectric composites that control light in ways not possible with traditional optics. To accomplish this, we have assembled a team of ...

When chelating-resin solid phase extraction (SPE) was used for the preconcentration of trace elements in environmental water samples around sewage treatment plants (STP), low recovery values several were observed. In present work, adverse effect coexisting EDTA on various during SPE procedure investigated detail. It found that contained at hundred nmol L?1 level, and interfered with adsorption ...

An automated on-line sample-preparation method using a computer-controlled pretreatment system (Auto-Pret AES system) coupled with ICP-AES was developed. In this work, an iminodiacetate chelating resin, packed in a mini-column and installed in the system was employed for the collection/concentration of 13 trace metals, including such toxic metals as Be, Cd, Cr, Cu and Pb. The limits of detectio...

We investigate the supercluster MS0302+17 (z ≈ 0.42) using weak lensing analysis and deep wide field BVR photometry with the CFH12K camera. Using (B-V) vs. (V-R) evolution tracks we identify supercluster early-types members and foreground ellipticals. We derive a R band background galaxies catalogue for weak lensing analysis. We compute the correlations functions of light and mass and their cro...