D-004, a lipid extract from royal palm (Roystonea regia) fruits, has shown to inhibit prostate 5-α-reductase in vitro, and to prevent prostate hyperplasia (PH) induced with T, not with DHT, in rodents, but its potential estrogenic or antiestrogenic effects had not been studied yet. This study investigated whether D-004 produces estrogenic or antiestrogenic effects, as assessed in the uterotroph...

A new inhibitor of acyl CoA:cholesterol acyltransferase (ACAT), HL-004 [N-(2, 6-diisopropylphenyl)tetradecylthioacetamide], suppressed the synthesis of cholesterol [14C]oleate at 10(-9) approximately 10(-7) M in a concentration-dependent manner in both THP-1 cell-derived macrophages and foam cells prepared from aortic intima of rabbits fed a high cholesterol diet. Incorporation of [3H]cholester...

We will now focus on the instance when k = 3, and we will denote the three alternatives as a, b, and c. For ease of notation, we will map each voter’s ranking, σi to a tuple (xi, yi, zi) ∈ {−1, 1}3, where xi = 1 if σi(a) > σi(b), and −1 otherwise. Similarly, yi = 1 if σi(b) > σi(c) and −1 otherwise, and zi = 1 if σi(c) > σi(a), and −1 otherwise. Finally, we will let x := (x1, . . . , xn), y := ...

Introduction With the increasing potential for targeted therapies in autoinflammatory diseases, there is the need for validated and standardized assessment tools which can be used to evaluate the level of disease activity and response to therapy.An international collaboration, initiated by Assistance Publique-Hôpitaux de Paris (APHP) in association with the Paediatric Rheumatology International...

Immunogenicity, manufacturing feasibility, and safety of a novel, autologous dendritic cell (DC)-based immunotherapy (AGS-004) was evaluated in ten human immunodeficiency virus type 1 (HIV-1)-infected adults successfully treated with antiretroviral therapy (ART). Personalized AGS-004 was produced from autologous monocyte-derived DCs electroporated with RNA encoding CD40L and HIV antigens (Gag, ...

NIP-004 is a novel synthetic compound developed to display human thrombopoietin (TPO) receptor (c-Mpl) agonist activity. NIP-004 displays species specificity, stimulating proliferation or differentiation of human c-Mpl-expressing cells such as UT-7/TPO and human CD34(+) cells but not murine c-Mpl-expressing cells or cynomolgus monkey cells. To test the mechanism of its action, we constructed mu...

Lyme disease is a tick-borne infectious disease caused by the spirochete Borrelia burgdorferi. Infection in most horses appears to be subclinical. Clinical signs most commonly attributed to Lyme disease in horses include low-grade fever, stiffness and lameness in more than one limb, muscle tenderness, hyperaesthesia, swollen joints, lethargy and behavioural changes. Diagnosis is made on the bas...