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The infectious diseases caused by multidrug-resistant bacteria pose serious threats to humankind. It has been suggested that an antibiotic targeting LpxC of the lipid A biosynthetic pathway in Gram-negative bacteria is a promising strategy for curing Gram-negative bacterial infections. However, experimental proof of this concept is lacking. Here, we describe our discovery and characterization o...
Objective: This study examines trends in the mortality of Alzheimer’s disease and other dementias China from 1990 to 2019. Methods: The data were drawn Global Burden Disease Study 2019 (GBD 2019), an age–period–cohort model was used for analysis. Results: net drift .152% (95% confidence interval [CI]: .069%, .235%) per year men ( P < .05) .024% CI: −.078%, .126%) women. local values below 0 ...
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