The chain packing in ordered phases of lipid bilayers can be classified according to wide-angle X-ray diffraction (WAXS). For triclinic (T(‖)) and monoclinic (M(‖)) packing in crystalline L(c) phases, the wide-angle reflections index on an oblique lattice with spacings s(10)≠s(01)≠s(11), and each chain has four nearest neighbours. For orthorhombic (O(⊥)) packing in L(c) phases, and the rotation...

Retinoic acid and Wnt/β-catenin signals play important roles during neuronal differentiation but less is known about noncanonical Wnt signals in this context. We examined retinoic acid and Wnt signaling in two human embryonal carcinoma cell lines, NTERA-2 (clone D1), which undergoes neuronal differentiation in response to retinoic acid, and 2102Ep, which does not. Retinoic acid treatment inhibi...

objective: β-thalassemia is caused by absence or reduction of β-globin chain synthesis. one of the effective therapeutic methods for this disease can be gene therapy by viral vectors. the capacity of lentiviral vectors is approximately 8 kb, we designed a 6 kb construct containing mini lcr and β-globin gene instead of lcr region. the aim of this study is to make a recombinant lentiviruses conta...

The membrane bound metalloprotease meprin β is important for collagen fibril assembly in connective tissue formation and for the detachment of the intestinal mucus layer for proper barrier function. Recent proteomic studies revealed dozens of putative new substrates of meprin β, including the amyloid precursor protein (APP). It was shown that APP is cleaved by meprin β in distinct ways, either ...

in circumstances such as in vitro fertilization (ivf) or in patients with luteal phase defect, one needs to ensure the establishment of pregnancy as soon as possible. at the same time, a question arises: how can a physician make sure that the β-hcg is of an endogenous source and not the residue of the prescribed drugs (hcg)? in this article we have studied the elimination time of 1m injection o...

Binary Ti-Fe alloys with 5-25 mass% Fe were prepared, and subjected to reciprocating wear test. The aim of this study was investigate the relationship between mechanical properties resistance titanium alloys. dimensions (length, width depth) marks on less than those observed pure Ti specimen. Wear better that titanium. It established hardness main factor influenced Single β showed α+β Increase ...

The solubility of trihexyphenidyl (Thp) was improved by its combination with β-cyclodextrin (β-CD) and modified β-CDs. The solubility of Thp was found to be increased in the presence of β-CD, hydroxypropyl-β-cyclodextrin (HP-β-CD), methyl-β-cyclodextrin (Me-β-CD) and sulfobutylether-β-cyclodextrin (SBE-β-CD). In particular, the solubility of Thp in conjunction with SBE-β-CD was increased by a f...

Two monoclinic (P21/c; Z′ = 1) polymorphs, α (from methanol) and β ethanol, n-propanol iso-propanol), of a bioactive pyrazolo[3,4-d]pyrimidine derivative have been isolated characterised by X-ray crystallography as well range computational chemistry techniques. The different conformations observed for the molecules in crystals are due to dictates molecular packing revealed geometry-optimisation...

The rat β-tropomyosin (TM) gene expresses two isoforms via alternative RNA splicing, namely skeletal muscle β-TM and fibroblast TM-1. The latter is also expressed in smooth muscle where it corresponds to smooth muscle β-TM. Skeletal muscle β-TM contains exons 7 and 10, whereas exons 6 and 11 are used in fibroblasts and smooth muscle. In order to study the properties of the alternatively spliced...

CONTEXT A decrease in pancreatic β-cell mass is involved in the development of type 2 diabetes. OBJECTIVE The purpose of this study was to evaluate the β-cell mass and the incidence of β-cell neogenesis, replication, and apoptosis at both the prediabetic and diabetic stages. METHODS We conducted a cross-sectional study of pancreatic tissues obtained from 42 patients undergoing a pancreatect...