BACKGROUND HIV drug resistance (HIVDR) testing is not routinely available in many resource-limited settings, therefore antiretroviral therapy (ART) program and site factors known to be associated with emergence of HIVDR should be monitored to optimize the quality of patient care and minimize the emergence of preventable HIVDR. METHODS In 2010, Namibia selected five World Health Organization E...

OBJECTIVE To determine whether a multimodal physiotherapy programme including taping, exercises, and massage is effective for knee osteoarthritis, and if benefits can be maintained with self management. METHODS Randomised, double blind, placebo controlled trial; 140 community volunteers with knee osteoarthritis participated and 119 completed the trial. Physiotherapy and placebo interventions ...

BACKGROUND The cyto-genetic hallmark of chronic myeloid leukaemia (CML), the Philadelphia chromosome (Ph), is the first consistent chromosomal abnormality that has been associated to a certain cancer type. In CML, Philadelphia chromosome is present leading to resistance to cell death and rapid proliferation. The aim of this study is to evaluate the different responses, toxicity and survival of ...

BACKGROUND The incidence of amyloidosis is difficult to determine because the disease is often undiagnosed or diagnosed incorrectly. In Polish studies, there are no statistics and analyses of the factors that may influence the development of amyloidosis in patients with multiple myeloma. OBJECTIVES The goal of this study was to estimate the incidence of AL amyloidosis in MM patients in Lower ...

BACKGROUND AND PURPOSE Despite the documented diagnostic value of local cerebral blood flow maps by xenon-enhanced computed tomography, reports of cerebral blood flow activation by inhaled 33% Xe raised concerns about the method's safety and accuracy. We evaluated the effect of 33% Xe inhalation on cerebral blood flow and cerebral metabolic rates for oxygen and glucose in four awake and six fen...

Five ruminally, duodenally, and ileally cannulated sheep (average BW 62 kg) were fed 65% roughage: 35% concentrate diets (CP = 15%) in a 5 x 5 Latin square design to study the applicability of using a combination of defaunation with N supplements (soybean meal [SBM], corn gluten meal [CGM], blood meal [BM], urea, and casein) with different extents of ruminal degradation to manipulate microbial ...

Philadelphia chromosome (Ph1)-positive acute lymphoblastic leukemia (ALL) has a poor prognosis when treated with conventional chemotherapy. We analyzed the outcome of 67 HLA-identical sibling bone marrow transplants (BMTs) for Ph1-positive ALL reported to the International Bone Marrow Transplant Registry (IBMTR). Twenty-one of 67 (31%) transplant recipients survived in continuous complete remis...

BACKGROUND Structured examination routines have been developed as educational resources for musculoskeletal clinical skills teaching, including Gait-Arms-Legs-Spine (GALS), Regional Examination of the Musculoskeletal System (REMS) and paediatric GALS (pGALS). In this study, we aimed to assess the awareness and use of these examination routines in undergraduate medical teaching in UK medical sch...

Moonlighting cell surface GAPDH recruits Apo Transferrin to effect iron egress from 1 mammalian cells 2 Navdeep Sheokand, Himanshu Malhotra, Santosh Kumar , Vikas Ajit Tillu, Anoop Singh 3 Chauhan, Chaaya Iyengar Raje and Manoj Raje∗ 4 Institute of Microbial Technology, CSIR, Sector 39A, Chandigarh, INDIA-160036. 5 2 National Institute of Pharmaceutical Education & Research, Phase X, Sector 67,...