نتایج جستجو برای: 13 dipolar cycloaddition

تعداد نتایج: 343672  

2018
Alejandra Riesco-Domínguez Jeroen van de Wiel Trevor A Hamlin Bas van Beek Stephen D Lindell Daniel Blanco-Ania F Matthias Bickelhaupt Floris P J T Rutjes

Trifluoromethyl vinyl sulfide, a potential building block for pharmaceutically and agrochemically relevant products, is prepared and used for the first time in high-pressure-mediated 1,3-dipolar cycloaddition reactions with nitrones to synthesize (trifluoromethyl)sulfanyl isoxazolidines.

Journal: :Chemical communications 2005
Joost A Opsteen Jan C M van Hest

Polymeric building blocks containing terminal azide and alkyne functionalities are prepared via atom transfer radical polymerization (ATRP) and used to modularly synthesize block copolymers via 1,3-dipolar cycloaddition reactions, which are quantitative according to SEC measurements.

Journal: :Bioorganic & medicinal chemistry letters 2007
Martijn Verdoes Ulrik Hillaert Bogdan I Florea Myra Sae-Heng Martijn D P Risseeuw Dmitri V Filippov Gijsbert A van der Marel Herman S Overkleeft

The synthesis of three acetylene functionalized BODIPY dyes is described. These dyes are used to fluorescently modify an azido functionalized epoxomicin analogue employing the Huisgen 1,3-dipolar cycloaddition, resulting in a panel of fluorescent epoxomicin derived proteasome probes.

Journal: :Organic & biomolecular chemistry 2012
Nagatoshi Nishiwaki Kazuya Kobiro Shotaro Hirao Jun Sawayama Kazuhiko Saigo Yumiko Ise Maho Nishizawa Masahiro Ariga

A new protocol for synthesizing different functionalized isoxazoles is provided. Carbamoylnitrile oxide generated from nitroisoxazolone underwent inverse electron-demand 1,3-dipolar cycloaddition with 1,3-dicarbonyl compounds in the presence of magnesium acetate that formed magnesium enolate in situ. Although electron-deficient trifluoroacetoacetate did not undergo this cycloaddition under the ...

Journal: :Molecules 2017
Alexander Anis'kov Irina Klochkova Roman Tumskiy Alevtina Yegorova

For the first time, arylmethylidene cyclohexanones that are non-symmetrical due to the presence of peripheral substituents were studied in 1,3-dipolar cycloaddition reactions. It is shown that the interaction with the azomethine ylide generated from sarcosine proceeds regio- and diastereoselectively, with the participation of two non-equivalent parts of the dipolarophile. Also for the first tim...

Journal: :Chemical communications 2011
Santosh B Salunke N Seshu Babu Chien-Tien Chen

A highly efficient and mild method for azido glycosylation of glycosyl β-peracetates to 1,2-trans glycosyl azides was developed by using inexpensive FeCl(3) as the catalyst. In addition, we demonstrated, for the first time, that FeCl(3) in combination with copper powder can promote 1,3-dipolar cycloaddition (click chemistry) of azido glycosides with terminal alkynes. Good to excellent yields we...

Journal: :Organic & biomolecular chemistry 2014
Mehdi Abaszadeh Mohammad Seifi

Ultrasound irradiation can promote the 1,3-dipolar cycloaddition reaction of 2-chloropyridinium ylides with 2-benzylidenemalononitrile or 2,2'-(1,4-phenylenebis(methanylylidene))dimalononitrile, to afford the indolizine and bis-indolizine derivatives respectively. While the reaction of pyridinium ylides with 2-benzylidenemalononitrile or 2,2'-(1,4-phenylenebis(methanylylidene))dimalononitrile u...

Journal: :Organic letters 2007
Mukund P Sibi Levi M Stanley Takahiro Soeta

[reaction: see text] A general strategy for highly enantioselective 1,3-dipolar cycloaddition of diazoesters to beta-substituted, alpha-substituted, and alpha,beta-disubstituted alpha,beta-unsaturated pyrazolidinone imides is described. Cycloadditions utilizing less reactive alpha,beta-disubstituted dipolarophiles require elevated reaction temperatures, but still provide the corresponding pyraz...

Journal: :Chemical communications 2007
Peter Carlqvist Feliu Maseras

Computational chemistry is used to study a 1,3-dipolar cycloaddition between an azide and an alkyne inside the macrocycle cucurbit[6]uril, in order to elucidate the catalytic function of a highly efficient supramolecular catalyst.

Journal: :Chemical communications 2011
Qing-Hua Li Min-Chao Tong Jun Li Hai-Yan Tao Chun-Jiang Wang

Trifluoromethylated pyrrolidines have been synthesized via catalytic asymmetric 1,3-dipolar cycloaddition with excellent stereoselectivity for the first time. Epimerization of the endo-pyrrolidines obtained from cis-4,4,4-trifluorocrotonate into the exo-pyrrolidines was also revealed.

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