نتایج جستجو برای: 131 mibg
تعداد نتایج: 17316 فیلتر نتایج به سال:
Malignant pheochromocytomas respond to chemotherapy with a reduction in tumor size and catecholamine secretion. We investigated the usefulness of molecular imaging with meta-iodobenzylguanidine (MIBG) for evaluating the effects of chemotherapy in patients with malignant pheochromocytoma. Six patients were studied before and after 6 ± 4 months of combination chemotherapy with cyclophosphamide, v...
OBJECTIVE Iodine-131-labelled meta-iodobenzylguanidine (I-mIBG) therapy is an established treatment modality for relapsed/refractory neuroblastoma, most frequently administered according to fixed or weight-based criteria. We evaluate response and toxicity following a dosimetry-based, individualized approach. MATERIALS AND METHODS A review of 44 treatments in 25 patients treated with I-mIBG th...
We report a case of 50 years old male with neurofibromatosis complaining of recurrent attacks of right loin pain. Clinically , the patient was normotensive , his body was full of neurofibromas with cafe au lait patches (Fig. 1, 2 & 3). Catecholamine in urine was markedly elevated. No other endocrinological abnormality depicted. CT scan abdomen revealed presence of right adrenal mass 5.9X5.9 cm ...
Keywords: false-positive result; [131I ]MIBG scan; renal neuroblastomas, and has had only limited success in other tumour types [1,2]. In our patient, the topo-artery stenosis graphic appearance of the MIBG accumulation corresponded exactly to the entire left kidney, as defined by diffuse homogeneously decreased MAG3 perfusion and uptake. Horne et al. supposed this accumulation to Renal history...
[¹³¹I]meta-iodobenzylguanidine ([¹³¹I]MIBG) is the most commonly used treatment for metastatic pheochromocytoma and paraganglioma. It enters the chromaffin cells via the membrane norepinephrine transporter; however, its success has been modest. We studied the ability of histone deacetylase (HDAC) inhibitors to enhance [¹²³I]MIBG uptake by tumors in a mouse metastatic pheochromocytoma model. HDA...
Objective: To compare the results of CT scanning and MIBG scintigraphy in the localization of phaeochromocytoma. Design: Retrospective study. Setting: University Hospital. Subjects: 24 patients with phaeochromocytoma who presented between 1983 and 1990. Results: In 21 out of 24 patients MIBG scintigraphy provided accurate localization. In 16 out of 18 patients who underwent CT scanning a correc...
PURPOSE (131)I-metaiodobenzylguanidine (MIBG) is a targeted radiopharmaceutical with activity in patients with relapsed or refractory neuroblastoma. Irinotecan is a known radiosensitizer with activity in neuroblastoma. This phase I study aimed to determine the recommended phase 2 dose of MIBG together with fixed doses of vincristine and irinotecan. EXPERIMENTAL DESIGN Patients 1 to 30 years o...
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