BACKGROUND Sustained heart rate abnormalities produce electrical remodeling and susceptibility to arrhythmia. Uncontrolled tachycardia produces heart failure and ventricular tachyarrhythmia susceptibility, whereas bradycardia promotes spontaneous torsade de pointes (TdP). This study compared arrhythmic phenotypes and molecular electrophysiological remodeling produced by tachycardia versus brady...

The preservation of the polarization level during acceleration of the electron beam is currently the main topic at the Electron Stretcher Accelerator (ELSA) of the University of Bonn. It can be improved by a good correction of the closed-orbit relative to the magnetic quadruple centres using the method of beam-based alignment. Beam position monitor electronics, developed in the Forschungszentru...

Importance Elevated systolic blood (SBP) pressure is a leading global health risk. Quantifying the levels of SBP is important to guide prevention policies and interventions. Objective To estimate the association between SBP of at least 110 to 115 mm Hg and SBP of 140 mm Hg or higher and the burden of different causes of death and disability by age and sex for 195 countries and territories, 19...

A 78-year-old man presented to his personal physician for a yearly examination. He was totally asymptomatic. Findings of a physical examination performed 1 year previously were normal, and an ECG displayed normal sinus rhythm (NSR) and minor nonspecific T-wave changes. Five years previously, he was found to have mild systemic hypertension and was administered combined hydochlorothiazide (25 mg)...

BACKGROUND Heart rate (HR) variability reflects the neural regulation of normal pacemaker tissue, but the autonomic nervous regulation of abnormal atrial foci originating outside the sinus node has not been well characterized. We compared the HR variability of tachycardias originating from the ectopic foci and the sinus node. METHODS AND RESULTS R-R-interval variability was analyzed from 24-h...

The medial septum (MS) plays an essential role in rhythmogenesis in the hippocampus (HIPP); theta-rhythmic bursts of MS neurons are believed to drive theta oscillations in rats' HIPP. The MS theta pacemaker hypothesis has solid foundation but the MS-hippocampal interactions during different behavioral states are poorly understood. The MS and the HIPP have reciprocal connections and it is not cl...

A 38-year-old female with rheumatic mitral stenosis on medical management presented with palpitations and presyncope since 10 days. Electrocardiogram showed an irregular rhythm at a rate of 160 bpm with preexcitation suggestive of atrial fibrillation with a left free wall accessory pathway (Fig. 1). Transthoracic echocardiography showed severe rheumatic mitral stenosis with a valve area of 1 cm...

We report on a 70-year-old male patient who was recipient of GEM III DR 7275 Cardioverter Defibrillator, and who presented with inappropriate shocks. The patient had a documented slow ventricular tachycardia (VT), and the device was programmed to detect VT at rates >100 bpm, fast VT (FVT, via VT) at rates >150 bpm, and ventricular fibrillation (VF) at rates >188 bpm. After detection of FVT, eff...

Abstract Background Atrioventricular nodal reentrant tachycardia (AVNRT) is most common supraventricular with acceptable outcome of catheter ablation. However, the serious complication atrioventricular block (AVB) can occur and affects 0.2% to 2.3% patients during or after procedures. Purpose We hypothesized that slow pathway ablation 20 watt (W) energy would facilitate clinical outcomes low pr...

The beam position monitor (BPM) system has been developed at BESSY and operates in 3 different modes: the closed orbit, the single turn, and the diagnostics mode. Details of the BPM system are presented together with the result of some bench tests. The commissioning of the system was done primarily with beam-based techniques and is described in more detail. First measurements of fast and slow b...