نتایج جستجو برای: 143
تعداد نتایج: 12454 فیلتر نتایج به سال:
اعمال قاعدۀ خرق حجاب شخصیت حقوقی بر مدیران، به طلبکاران شرکت های تجاری اجازه می دهد بدون درخواست ورشکستگی یا انحلال شرکت، خسارت های مازاد بر سرمایۀ وارد بر خود را از مدیران مطالبه کنند. قاعدۀ خرق حجاب خود سبب دعوای مجزایی نیست و تنها دادگاه را مجاز می سازد در حالی که شخصیت حقوقی شرکت باقی است، مدیران را مسئول جبران خسارت های جبران نشده قرار دهد. بنابراین، مراجعه به مدیران سبب مستقلی نیاز دارد و...
MicroRNAs (miRNAs) play an essential role in the onset and development of many cardiovascular diseases. Increasing evidence shows that miRNAs can be used as potential diagnostic biomarkers for cardiovascular diseases, and miRNA-based therapy may be a promising therapy for the treatment of cardiovascular diseases. The microRNA-143/-145 (miR-143/-145) cluster is essential for differentiation of v...
Endometrial cancer (EC) is one of the most commonly diagnosed gynecologic malignancies in the world, with the morbidity rate of over 7%. The mechanism of the pathogenesis has not been specifically elucidated to date, which is imperative for EC treatment. The aim of our study was to investigate the target relationship between miR-143 and mitogen-activated protein kinase 1 (MAPK1) and explore the...
MicroRNAs (miRNAs), 18-24 nt non-coding RNAs, are thought to play important roles in cell proliferation, differentiation, apoptosis, and development. Recent studies suggest that some of the known microRNAs map to a single genomic locale within a single polycistronic transcript. But the roles of the cluster remain to be known. In order to understand the role and mechanism of a cluster of miR-143...
Smooth muscle cells (SMCs) retain remarkable plasticity to undergo phenotypic modulation in which the expression of smooth muscle markers is markedly attenuated while conversely expression of extracellular matrix (ECM) is dramatically up-regulated. Myocardin is perhaps the most potent transcription factor for stimulating expression of smooth muscle-specific genes; little is known, however, abou...
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