PURPOSE The aim of this study was to evaluate the degree of metastatic bone pain palliation and medullar toxicity associated with samarium-153-EDTMP treatment. METHODS Seventy-three patients with metastatic bone pain having previously undergone therapy with samarium-153-EDTMP (1 mCi/kg) were retrospectively evaluated. Routine follow-up included pain evaluation and blood counts for 2 months af...

background: therapeutic radiopharmaceuticals are designed to deliver high doses of radiation to selected target organs with an aim of minimizing unwanted radiation to surrounding healthy tissue. due to the potential of targeted radiotherapy to treat a wide range of malignant conditions, [153sm]-samarium maltolate was developed for possible therapeutic applications. materials and methods: the or...

Background: Therapeutic radiopharmaceuticals are designed to deliver high doses of radiation to selected target organs with an aim of minimizing unwanted radiation to surrounding healthy tissue. Due to the potential of targeted radiotherapy to treat a wide range of malignant conditions, [153Sm]-samarium maltolate was developed for possible therapeutic applications. Materials and Methods: The or...

INTRODUCTION Particle-emitting, bone-seeking radiopharmaceuticals have attracted the attention of the nuclear medicine community over the last three decades for the treatment of the pain of osteoblastic metastases. The objectives of this research were to produce quality-controlled (159)Gd-EDTMP in order to provide a new therapeutic radiopharmaceutical for use in clinical applications. METHODS...

Tera Becquerel quantities of a number of radioisotopes such as 131I, 99Mo, 32P, 153Sm, 51Cr, 82Br, 203Hg, 140La, 46Sc, etc. are produced in various radiochemical forms and regularly supplied through Board of Radiation & Isotope Technology (BRIT) for applications in medicine, industry, biology, agriculture and research & development activities. These radioisotopes are produced by neutron activat...

Background: Owing to its favourable decay characteristics 177Lu [T1/2= 6.71 d, Eβ(max)= 497 keV] is an attractive radionuclide for various therapeutic applications. Ethylene diamine tatramethylene phosphonate (EDTMP) is one of the most widely used ligands which form stable complexes with various radionuclides and all the complexes. Materials and Methods: Enriched 176Lu2O3 was dissolve...

   Developing new bone pain palliation agents is a mandate in handling end-stage cancer patients around the world. Possibly, Lu-177 ethylenediaminetetramethylene phosphonic acid (177Lu-EDTMP) is a therapeutic agent which can be widely used in bone palliation therapy. In this study, 177Lu-EDTMP complex was prepared successfully using synthesized EDTMP ligand and 177LuCl3. Lu-177 chloride was obt...

OBJECTIVES This study describes the preparation, biodistribution of 153Sm-DTPA-SPION after intravenous injection in rats. MATERIALS AND METHODS The chelator DTPA dianhydride was conjugated to SPION using a small modification of the well-known cyclic anhydride method. Conjugation was done at a 1: 4 (SPION:ccDTPA) molar ratio. Conjugation reaction was purified with magnetic assorting column (MA...

Introduction Compartmental analysis allows the mathematical separation of tissues and organs to determine activity concentration in each point of interest. Biodistribution studies on humans are costly and complicated, whereas such assessments can be easily performed on rodents. In this study, we aimed to develop a pharmacokinetic model of 153Sm-maltolate complex as a novel therapeutic agent and...

Radionuclide therapy is widely used as an effective modality in the management of bone pain. The main indication for this treatment is symptomatic bone metastases, confirmed by bone scintigraphy. We present a case of small cell lung cancer (SCLC) stage T4N2M1b, with a good metabolic response to systemic therapy and radiotherapy of the primary tumor and locoregional disease, which became metabol...