To identify novel proteins regulating the microtubule cytoskeleton, we screened a library of purine derivatives using mitotic spindle assembly in Xenopus egg extracts as an assay. Out of a collection of 1561 compounds, we identified 15 that destabilized microtubules without targeting tubulin directly, resulting in small spindles. Affinity chromatography with one compound, named diminutol, revea...

the period. However, in his book De Glandulis, Hippocrates (460-337 BC) states in relation to the glands: “……when glands of the neck become diseased themselves, they become tubercular and produce struma……”. The term “struma” is still used in some European countries (e.g. Austria, Italy) as the medical designation of goiter. In addition, in the Hippocratic writings of the 4 century BC, we encoun...

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Recently an exact solution has been found by M. Henkel and H. Hinrichsen [J. Phys. A 34, 1561 (2001)] for the one-dimensional coagulation-production process: 2A-->A, AØA-->3A with equal diffusion and coagulation rates. This model evolves into the inactive phase independently of the production rate with t(-1/2) density decay law. This paper shows that cluster mean-field approximations and Monte ...