Foy, M. R., J. Xu, X. Xie, R. D. Brinton, R. F. Thompson, and T. W. Berger. 17b-estradiol enhances NMDA receptor-mediated EPSPs and long-term potentiation. J. Neurophysiol. 81: 925–929, 1999. Gonadal steroid hormones influence CNS functioning through a variety of different mechanisms. To test the hypothesis that estrogen modulates synaptic plasticity in the hippocampus, in vitro hippocampal sli...

This report continues a discussion begun in the LCIS-98-17B report. As for the Ateniese-Tsudik schemes, we show that both the ID-based and self-certified public keys based group signature schemes proposed by Tseng and Jan (1998/1999) are not coalition-resistant: two colluding group members can produce untraceable group signatures. Indexing terms: Digital signatures, Group signatures

Hayward, Christopher S., Wally V. Kalnins, and Raymond P. Kelly. Acute effects of 17b-estradiol on ventricular and vascular hemodynamics in postmenopausal women. Am J Physiol Heart Circ Physiol 279: H2277–H2284, 2000.—Because premenopausal women have lower cardiovascular morbidity than postmenopausal women, it has been proposed that estrogen may have a protective role. Estrogen is involved in s...

Oral estrogen administration decreases plasma levels of tissue-type plasminogen activator (tPA), which may be explained by a decrease in endothelial tPA synthesis, an increase in its hepatic clearance, or both. In the present study, we determined (1) differences between oral (ie, via the liver) ethinyl estradiol and transdermal (ie, systemic) 17b-estradiol administration on plasma antigen level...

An import role for gonadal steroid hormones, particularly testosterone, in mediating aggressive behavior is well‐established across vertebrate taxa. Due to the emphasis placed on testosterone much less is know regarding the potential role of other steroid and peptide hormones in the regulation of aggression. The idea that any single hormone mediates aggression, however, is overly simplistic. In...

Some estrogenic compounds modify vascular smooth muscle cell (SMC) biology; however, whether such effects are mediated in part by estrogen receptors is unknown. The purpose of this study was to evaluate whether the actions of clinically used estrogens on human aortic SMC biology are mediated by estrogen receptors. We examined the effects of various clinically used estrogens in the presence and ...

Intensive screening has improved our understanding of the profile of mutations in the CFTR gene in which more than 400 mutations have been detected to date. In collaboration with several European laboratories we are involved in such analysis. We have identified 14 new mutations in exon 17b of CFTR, having analysed 780 CF chromosomes, and have compared the frequency of mutations in this exon wit...

The development of male attributes such as external genitalia and secondary sexual characteristics is due to a hormone called testosterone produced in the testicles. This hormone is also responsible for the development and maintenance of muscle mass (Griggs et al., 1989), bone density, red blood cell counts (Bachman et al., 2014), supports sexual and reproductive function and contribute to a ma...