BACKGROUND The aim of this study was to investigate whether the maximum standardized uptake value (SUVmax) measured on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) could be used as the primary means of differential diagnosis of thyroid nodules when tumor volume is assessed. METHODS We studied 192 patients who underwent preoperative 18F-FDG P...

INTRODUCTION Gliomas, the most commonly diagnosed primary brain tumours, are associated with varied survivals based, in part, on their histological subtype. Therefore, accurate pretreatment tumour grading is essential for patient care and clinical trial design. METHODS AND ANALYSIS We will perform an individual-level data meta-analysis of published studies to evaluate the ability of different...

BACKGROUND Fluorine-18 dihydrotetrabenazine [DTBZ] analogues, which selectively target the vesicular monoamine transporter 2 [VMAT2], have been extensively studied for in vivo quantification of beta cell mass by positron-emission tomography [PET]. This study describes a novel deuterated radioligand [18F]fluoroethyl [FE]-DTBZ-d4, aimed to increase the stability against in vivo defluorination pre...

Background: Fluoride-18 is the most widely used radioisotope for Positron Emission Tomography (PET). [18F] 2-flouro- 2-deoxy D-glucose (FDG) has become a standard tool in the area of clinical research. The oxygen-18 enriched water is the most widely used target for the production of fluoride-18. The use of the nuclear reaction 18O (p,n)18F has been found as the most effective method for the pro...

Interleukin-2 (IL2) is a cytokine that can stimulate cytotoxic immune cells to attack infected and malignant cells. Unfortunately, IL2 can also cause serious immune-related toxicity. Recently, a mutant of IL2 (IL2v) with abolished CD25 binding, increased plasma half-life and less toxicity was engineered. Unlike wild-type IL2 (wt-IL2), mutant IL2v does not bind to the α-subunit (CD25) of the hig...

gliomas account for almost 80% of primary malignant brain tumors in adults. magnetic resonance imaging (mri) is still the gold standard for diagnosis of brain tumors and brain 99mtc-tetrofosmin single photon emission computed tomography (99mtc-tetrofosmin-spect) has been established as a useful tool for their evaluation. fluorine-18–2-fluoro-2-deoxy-d-glucose positron emission tomography/comput...

OBJECTIVES To determine whether an increase in cardiac sympathetic activity produced by exercise or sublingual glyceryl trinitrate causes an increased rate of loss of fluorine-18 from the myocardium after intravenous [18F]6-fluorodopamine ([18F]F-DA) in normal volunteers. In addition, to determine the contribution of non-specific uptake of [18F]F-DA in the myocardium in patients with recent hea...

b-cell lymphoblastic lymphoma (b-lbl) is an uncommon subtype of pediatric non-hodgkin lymphoma (nhl) which rarely involves the skin primarily. the positron emission tomography with 2-deoxy-2-[fluorine- 18] fluoro-d: -glucose integrated with computed tomography (18f-fdg pet/ct) scan findings of a 8-year-old boy with cutaneous b-lbl were presented. pet/ct scan demonstrated mild fdg uptake in the ...

Objective(s): We performed a phase IIa clinical trial of trans-1-amino-3-18Ffluoro-cyclobutane carboxylic acid (anti-18F-FACBC), a synthetic amino acid analog for PET, in patients with metastatic prostate cancer. Methods: The study subjects consisted of 10 untreated prostate cancer patients having lymph node and/or bone metastasis. Five patients underwent whole-body PET 5 and 30 min after intra...

UNLABELLED Osteomyelitis complicates up to one third of diabetic foot infections, is often due to direct contamination from a soft-tissue lesion, and represents a clinical challenge. Early diagnosis is important since antibiotic therapy can be curative and may prevent amputation. The present study assessed the role of PET/CT using 18F-FDG for the diagnosis of diabetic foot osteomyelitis. METH...