Background The aim of this study was to evaluate the palliative efficacy of localized external radiotherapy (RT) combined with systemic radionuclide (RN) therapy in patients who had multiple painful osseous metastases of different primary origins. Methods Thirty-three patients initially local external radiotherapy was delivered to the most symptomatic region in all patients. Then they receive...

Despite standard treatment, about 70% of ovarian cancer will recur. Cancer stem cells (CSCs) have been implicated in the drug-resistance mechanism. Several drug resistance mechanisms have been proposed, and among these, autophagy plays a crucial role for the maintenance and tumorigenicity of CSCs. Compared to their differentiated counterparts, CSCs have been demonstrated to display a significan...

In inertial confinement fusion (ICF) and high-energy density physics (HEDP), the most important manifestations of the hydrodynamic instabilities and other mixing processes involve lateral motion of the accelerated plasmas. In order to understand the experimental observations and to advance the numerical simulation codes to the point of predictive capability, it is critically important to accura...

Glioblastoma (GBM) is the most frequent and aggressive primary adult brain tumor with poor prognosis. Epidermal growth factor receptor variant III (EGFRvIII) is the most common and highly oncogenic EGFR mutant in GBM. With the aim to generate specific molecular probes able to target EGFRvIII with high affinity, we selected four DNA aptamers (U2, U8, U19 and U31) specifically bound to U87-EGFRvI...

Pulsed plasmas in liquids exhibit complex interaction between three phases of matter (liquids, gas, plasmas) and are currently used a wide range applications across several fields, however significant knowledge gaps our understanding plasma initiation hinder additional application control; this area research lacks comprehensive predictive model. To aid progress experimentally, here we present t...

The twoand three-dimensional ~2D and 3D! versions of ALEGRA-HEDP @A. C. Robinson and C. J. Garasi, ‘‘Three-dimensional Z-pinch wire array modeling,’’ Computer Physics Communications, submitted# have been utilized to simulate discrete wire effects including precursor formation in 2D (r-u plane! and nonuniform axial ablation ~3D!. Comparisons made between 2D and 3D simulations indicate that 2D si...