NALIDIXIC ACID, one of a series of 1, 8naphthyridine derivatives with antibacterial activity was synthesised by Lesher, Froelich, Gruett, Bailey and Brundage (1962). Chemically it is l-ethyl-7-methyl-1, 8-naphthyridine-4-one3-carboxylic acid. The pharmacology and toxicology have been documented by Ward-McQuaid, Jichlinski and Macis (1963) and Lishman and Swinney (1963), based on unpublished inf...

Indomethacin is an indole-3-acetic acid derivative (Fig. 1), which has been shown by animal experiments to possess powerful anti-inflammatory and anti-pyretic properties without evidence of toxicity other than causing diarrhoea and gastro-intestinal irritation when given in excessive dosage (Hodgkinson, 1963). Preliminary reports of its action in arthritic patients have been given at the Americ...

NALIDIXIC ACID, one of a series of 1, 8naphthyridine derivatives with antibacterial activity was synthesised by Lesher, Froelich, Gruett, Bailey and Brundage (1962). Chemically it is l-ethyl-7-methyl-1, 8-naphthyridine-4-one3-carboxylic acid. The pharmacology and toxicology have been documented by Ward-McQuaid, Jichlinski and Macis (1963) and Lishman and Swinney (1963), based on unpublished inf...

NALIDIXIC ACID, one of a series of 1, 8naphthyridine derivatives with antibacterial activity was synthesised by Lesher, Froelich, Gruett, Bailey and Brundage (1962). Chemically it is l-ethyl-7-methyl-1, 8-naphthyridine-4-one3-carboxylic acid. The pharmacology and toxicology have been documented by Ward-McQuaid, Jichlinski and Macis (1963) and Lishman and Swinney (1963), based on unpublished inf...

11 Felsenfeld, G., G. Sandeen, and P. von Hippel, these PROCEEDINGS, 50, 644 (1963). 12Bollum, F. J., J. Cell. Comp. Physiol., 62 (Suppi. 1), 61 (1963); Von Borstel, R. C., D. M. Prescott, and F. J. Bollum, J. Cell Biol., 19, 72A (1963). 13 Huang, R. C., and J. Bonner, these PROCEEDINGS, 48, 216 (1962); Allfrey, V. G., V. C. Littau, and A. E. Mirsky, these PROCEEDINGS, 49, 414 (1963). 14 Baxill...

dr:Y fl96.?‘). \_ _-, .~ % 18.5 39.1 30.0 36.7 44.6 w sot 491 7. ZERNER, B., AND BENDER, M. L., J. Am. Chem. Sot., 86, 356 (1963). 8. JENCKS, W. P., J. Am. Chem. Sot., 80,458l (1958). 9. CAPLOW, M., AND JENCKS, W. P., J. Biol. Chem., 238, PC3140 (1963). 10. BENDEH,M. L., CLEMENT,G. E., GUNTER,~. R., AND KEZDY, F. J., J. Biol. Chem., 238, PC3143 (1963). 11. EPAND, R. M., AND WILSON, I. B., J. Bi...

Specific lung changes occur in association with rheumatoid arthritis but rheumatoid lung nodules unassociated with pneumoconiosis are rare and there are very few reports of cavitation occurring in such nodules (Sieniewicz, Martin, Moore, and Miller, 1962; Noonan, Taylor, and Engleman, 1963; Dumas, Gregory, and Ozer, 1963; Locke, 1963; Yates, 1963). This paper describes another patient in whom r...

A striking feature of paralytic poliomyelitis has been its ever changing epidemiology. In the past, changes seem to have come about in the course of natural evolution from an endemic to an epidemic pattern, first in one part of the world, and then in another. At present, the use of effective vaccines for prevention and for greatly reducing circulation of wild strains of the virus, have apparent...