Sodium citrate as a highly efficient catalyst is developed for the synthesis of functionalized 2-amino-3-cyano-4H-pyrans and pyran-annulated heterocycles. This method involves one-pot three-component reaction aromatic aldehydes, malononitrile 1,3-dicarbonyl compounds with EtOH: H2O (1:1 v/v) solvent under room temperature. protocol presents several advantages such shorter time, utilization eco-...

Electrochemical synthesis suggested a mild, green and atom-efficient route to interesting useful molecules, thus avoiding harsh chemical oxidizing reducing agents used in traditional synthetic methods. Organic electrochemistry offers an excellent alternative conventional methods of organic creates modern tool for carrying out synthesis, including cascade multicomponent ones. In this research, n...

The asymmetric unit of the title compound, C(25)H(22)OS, comprises two similar 4-(4-methoxy-phen-yl)-4-methyl-2,6-diphenyl-4H-thio-pyran mol-ecules. In each, the six-membered thio-pyran ring adopts a planar conformation (r.m.s. deviation of 0.041Å for the ring in one mol-ecule and 0.008 Å in the other). The methoxy-phenyl substituent is in a pseudo-axial position. The crystal studied is an inve...

The reactions of 2-perfluoroacyl-1H-benzo[f]chromenes and 6,7-dimethyl-3-trifluoroacetyl-4H-chromene with primary aliphatic amines ammonia afforded a series enamino ketones containing (2-hydroxynaphthalen-1-yl)methyl or 2-hydroxybenzyl substituent in the ?-position respect to carbonyl group. These involved opening pyran ring, which followed aza-Michael addition as initial step. obtained were fo...

In the title compound, C(6)H(6)O(4), inter- and intra-molecular hydrogen bonds are observed which help to establish the crystal structure. There are weak π-π interactions between pyran rings separated by 3.5692 (9) Å.

The title compound, C(6)H(6)O(3), is a member of the pyrone family. The mol-ecules are planar (r.m.s. deviation of the asymmetric unit is 0.0248 Å, whereas that of the dimer is 0.0360 Å) and they are dimerized due to inter-molecular O-H⋯O hydrogen bonds. The dimers are connected to each other through hydrogen bonds involving the CH(3) group and the hydr-oxy O atom. There are π-π inter-actions b...

Introduction: Due to the cell labeling potentials of various metal-maltol complexes, the idea of developing a possible cell labeling imaging agent using single photon emission computed chromatography (SPECT) with[111In]-maltolate complex has been investigated. Methods: [111In] labeled 3-hydroxy-2-methyl-4H-pyran-4-onate ([111In]-maltolate) was prepared using f...

Two novel 3-amino-5-(4-choloro-2-phenoxyphenyl)-4H-1,2,4-triazole derivatives were prepared and their anticonvulsant activity was measured by evaluation of the ability of these compounds to protect mice against convulsion induced by lethal doses of pentylenetetrazole (PTZ). Diazepam (Sigma) was considered as a positive control drug with anticonvulsant effect [ED50 = 1.2 (0.5-1.9) mg/Kg]. Amongs...

A new series of some biologically active Cr(III), Fe(III), Co(II), Ni(II), Cu(II), and Zn(II) complexes was synthesized from the reaction Ethyl 6-amino-4-(4-chlorophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate (L) with previous biological metals in presence 1,10-phenanthroline monohydrate (Phen). The structures obtained L along their were authenticated by different analytical spectral techniqu...