We investigated effects of poly(ADP-ribose) synthetase (PARS) inhibitors on acoustic trauma. Albino guinea pigs were intravenously given 3-aminobenzamide, nicotinamide or 3-aminobenzoic acid (an inactive analog of 3-aminobenzamide) just prior to exposure to a 2 kHz pure tone of 120 dB sound pressure level (SPL) for 10 minutes. The threshold of the compound action potential (CAP) and the amplitu...

Aminocarboxylic acids, such as 2-aminobenzoic acid, react easily with [Ir(COD)(PMe3)3]Cl, (COD=1,5-cyclooctadiene), in THF to produce hydridoaminocarboxylato iridium(III) complexes in high yields. These octahedral complexes are formed via oxidative addition reaction of the O-H bond of the carboxylic group with the central metal. The starting iridium(I) complex losses t...

five new aromatic poly(amide-imide)s (5a-e) were synthesized by direct polycondensationreaction of n-(4-carboxy phenyl) trimellitimide (3) with five aromatic diamines (4a-e) by usingtriphenyl phosphite in n-methyl-2-pyrrolidone (nmp) and pyridine at solution containingdissolved cacl2. all of the polymers were obtained in quantitative yields with inherentviscosities between 0.29-0.40 dl/g. the r...

The shikimate pathway presents an attractive target for malaria chemotherapy. Three shikimic acid analogs exhibited different effects on Plasmodium falciparum growth. (6R)-6-Fluoro-shikimate and (6S)-6-fluoro-shikimate inhibited growth (50% inhibitory concentrations, 1.5 x 10(-5) and 2.7 x 10(-4) M, respectively), whereas 2-fluoro-shikimate had no effect. para-Aminobenzoic acid abrogated the in...

The kinetics of p-aminobenzoic acid oxidation catalyzed by horseradish peroxidase Compounds I and II was investigated intensively as a function of pH at 25 degrees in aqueous solutions of ionic strength 0.11. All of the rate data were collected from single turnover experiments involving reactions of a single enzyme compound. In reactions of both compounds, deviations from first order behavior w...

The first indication that p-aminobenzoic acid is concerned in the synthesis of methionine by microorganisms was the observation that methionine, under appropriate conditions, overcame inhibition of growth by sulphonamides in a non-competitive manner (Harris & Kohn, 1941; Kohn, 1943; Bliss & Long, 1941). Since then methionine has frequently been shown with various organisms to be an essential co...

Glucose. ...................... Sodium acetate (anhydrous). ... Salts A K~HPOI ..................... KHzPOr .................... Salts B MgSOa.7HzO. ................ MnS01.4H20. ............... NaCl ........................ FeSO,.7HzO .................. Adenine ....................... Guanine ....................... Uracil ......................... Thiamine chloride. ............. Pyridoxamine ...

Abstract Development of latent prints employing cyanoacrylate ester (CA) can be a multistep process including CA fuming and subsequent fluorescent staining to produce fingerprints sufficient contrast for comparison work. To enable single‐step fuming—staining process, selection fluorophores have been developed as sublimation dyes in fuming. A greater array such luminescent would allow users flex...