A study was conducted to investigate the effect of feeding diets containing different levels of aflatoxin B1 (AF) viz., 0, 300, 400 and 500ppb on the performance of broiler breeders. The breeder hens aged 28 weeks were fed with four treatment diets: Control (0ppm), (300 ppb), (400 ppb) and (500 ppb) for three periods, each with a duration of three weeks from 28 to 36 weeks of age. Feeding of AF...

Aflatoxin B1 (AFB1) is a hepatocarcinogen produced by certain Aspergillus species growing on crops. After biotransformation in the liver, AFB1 generates several metabolites, one of which is AFB1 bound to lysine on serum albumin. AFB1-lysine (AFB1-lys) is a digest product of AFB1-albumin and is considered a biomarker of exposure to AFB1 in humans and animals. The objectives of this paper were to...

The chemopreventive effects of kolaviron, a natural antioxidant bioflavonoid from the seeds of Garcinia kola, on aflatoxin B1 (AFB1)-induced genotoxicity and hepatic oxidative damage was investigated in rats. Kolaviron administered orally at a dose of 200 mg/kg once a day for the first 2 weeks and then 100 mg/kg twice a day for the last 4 weeks of AFB1 (2 mg/kg, single dose, intraperitoneal) tr...

A study was conducted to investigate the effect of feeding diets containing different levels of aflatoxin B1 (AF) viz., 0, 300, 400 and 500ppb on the hatching egg quality of broiler breeders. The breeder hens aged 28 weeks were fed with four treatment diets: Control (0ppm), (300 ppb), (400 ppb) and (500 ppb) for three periods, each with a duration of three weeks from 28 to 36 weeks of age. Feed...

A 3-week-feeding study (1-21 d post-hatch) was conducted to evaluate the efficacy of total curcuminoids (TCMN), as an antioxidant, to ameliorate the adverse effects of aflatoxin B1 (AFB1) in broiler chickens. Turmeric powder (Curcuma longa L.) that contained 2.55 % TCMN was used as a source of TCMN. Six cage replicates of five chicks each were assigned to each of six dietary treatments, which i...

This review paper describes briefly on the history of aflatoxins, the metabolism of aflatoxin B1 (AFB1) that leads to the activation and detoxification of AFB1, and the findings of some of the studies relating to food nutrients and additives, and drugs on AFBJ carcinogenicity and detoxification. Aflatoxins have been linked to many public health problems, especially to liver cancer incidences, i...

Animal feeding studies have demonstrated that clay additives, such as bentonites, can bind aflatoxins in ingested feed and reduce or eliminate the toxicity. Bentonite deposits are found throughout the world and mostly consist of expandable smectite minerals, such as montmorillonite. The surfaces of smectite minerals can be treated with organic compounds to create surface-modified clays that mor...

Purpose: Cognitive deficit is one of the common comorbidity accompanying epilepsy. The present study evaluated the effect of Celastrus paniculatus (C- paniculatus) seed extract on seizure severity and cognitive deficit following Pentylenetetrazole (PTZ) -induced chemical kindling model. Methods: PTZ kindling model was developed by daily administration of sub-convulsive dose of PTZ 30 mg/kg for...

Aflatoxins (AF) are mycotoxins derived by Aspergillus flavus and Aspergillus parasiticus and are listed as Group I carcinogens by the International Agency for Research on Cancer (IARC), a body of the World Health Organization. The main aflatoxins are the B1 (AFB1), B2, G1 and G2 together with their metabolites, among which the most important is the aflatoxin B1. AFB1 is the molecule with the hi...